Catalytic Synthesis of Pyrazolo[3,4-d]pyrimidin-6-ol and Pyrazolo[3,4-d]pyrimidine-6-thiol Derivatives Using Nanoparticles of NaX Zeolite as Green Catalyst

Table 1

Synthesis of several pyrazolone-pyrimidine derivatives using urea and nanoparticles of NaX zeolite catalyst.

Entry	Product	Time (h)	^aYield (%)	MP (°C)
1	4a, -H	1	90	185
2	4b, 4-OH	1.5	95.5	171
3	4c, 3-OH	1.5	93.5	156
4	4d, 2-OH	1.5	91	166
5	4e, 4-Cl	2.5	84	154
6	4f, 3-Cl	2.5	80	150
7	4g, 4-CH3	1	92	138
8	4h, 4-OCH3	1	94	145
9	4i, 3-NO2	3	77	188
10	4j, 4-NO2	3	81	183
11	4k, 4-F	3.5	71	124

aIsolated yield.