Catalytic Synthesis of Pyrazolo[3,4-d]pyrimidin-6-ol and Pyrazolo[3,4-d]pyrimidine-6-thiol Derivatives Using Nanoparticles of NaX Zeolite as Green Catalyst

Table 2

Synthesis of several pyrazolone-pyrimidine derivatives using thiourea and nanoparticles of NaX zeolite catalyst.

Entry	Product	Time (min)	^aYield (%)	MP (°C)
1	4a, -H	1	91	186
2	4b, 4-OH	1.5	96.5	180
3	4c, 3-OH	1.5	93	176
4	4d, 2-OH	1.5	91.5	184
5	4e, 4-Cl	2.5	84	181
6	4f, 3-Cl	2.5	80	185
7	4g, 4-CH3	1	92.5	182
8	4h, 4-OCH3	1	95	285
9	4i, 3-NO2	3	76	216
10	4j, 4-NO2	3	81.5	224
11	4k, 4-F	3.5	72	151

aIsolated yield.