Ceric Ion Loaded MCM-41 Catalyzed Synthesis of Substituted Mono- and Bis-dihydropyrimidin-2(1H)-ones

Table 2

Ce-MCM-41 catalyzed synthesis of 3,4-dihydropyrimidinones^a.

S. no.	𝑅^1	𝑅^2	𝑋	Product	Time (h)	Yield (%)^b
1	H	Et	O	4a	1.0	94
2	4-OMe	Et	O	4b	1.5	90
3	4-Cl	Et	O	4c	1.0	93
4	4-NO2	Et	O	4d	1.5	89
5	4-OH	Et	O	4e	1.5	88
6	2-OH	Et	O	4f	2.0	87
7	2-Cl	Et	O	4g	1.5	84
8	3-NO2	Et	O	4h	2.0	86
9	2-NO2	Et	O	4i	1.0	81
10	H	Me	O	4j	1.0	93
11	4-Cl	Me	O	4k	1.0	90
12	4-NO2	Me	O	4l	1.5	87
13	3-NO2	Me	O	4m	2.0	85
14	2-OH	Me	O	4n	1.5	83
15	4-OCH3	Me	O	4o	2.0	89
16	H	Et	S	4p	1.0	89
17	4-Cl	Et	S	4q	1.5	91
18	4-NO2	Et	S	4r	1.5	86
19	3-NO2	Et	S	4s	1.5	84
20	H	Me	S	4t	1.0	90
21	4-Cl	Me	S	4u	1.0	91
22	4-NO2	Me	S	4v	1.5	87

aCe-MCM-41 catalyzed Biginelli reaction under solvent-free conditions.
^bIsolated yields.