The Influence of Smoking, Gender, and Family History on Colorectal Adenomas

Table 4

Stratified logistic regression models of smoking and adenoma occurrence among individuals undergoing screening colonoscopy in the New Hampshire colonscopy Registry from 2004–2006.

	Adenoma v. No Adenoma
Model	Odds Ratio (95%Cl)^a
Full Model (𝑛=5,395)
Smoking
No pack-years	1.00 (referent)
15 pack-years or fewer	1.07 (0.87–1.32)
More than 15 pack-years	1.54 (1.28-1.86)^‡
Sex
Men	1.00 (referent)
Women	0.53(0.45-0.62)^‡
FamilyHistory^b
Negative	1.00 (referent)
Positive	1.73(1.40-2.15)^‡
Stratified by Sex
Male (𝑛=2,284)
No pack-years	1.00 (referent)
15 pack-years or fewer	1.32(1.00-1.76)^†
More than 15 pack-years	1.55(1.21-2.00)^‡
Female (𝑛=3,111)
No pack-years	1.00 (referent)
15 pack-years or fewer	0.85 (0.61–1.14)
More than 15 pack-years	1.55(1.17-2.05)^‡
Stratified by Family History
Negative (𝑛=4,649)
No pack-years	1.00 (referent)
15 pack-years or fewer	1.16 (0.92–1.46)
More than 15 pack-years	1.56(1.27-1.91^‡)
Positive (𝑛=746)
No pack-years	1.00 (referent)
15 pack-years or fewer	0.77 (0.4 7–1.26)
More than 15 pack-years	1.50 (0.94–2.38)

^aOdds ratios are adjusted for age in all models, and for family history in the sex-stratified models, and for sex in the family history-stratified models. ^bFamily history was defined as a reported diagnosis of colon or rectal cancer in a mother, father, sibling, or child of the patient.
^†𝑃=.05.
^‡𝑃≤.001.