Journal of Cancer Epidemiology

Research Article

Risk of Late Mortality and Second Malignant Neoplasms among 5-Year Survivors of Young Adult Cancer: A Report of the Childhood, Adolescent, and Young Adult Cancer Survivors Research Program

Table 2

Observed and expected deaths, standard mortality ratio, and absolute excess risk for death by sexf.
γ€€Entire cohort ( 𝑁 = 1 2 4 8 )Male ( 𝑁 = 5 8 9 )Female ( 𝑁 = 6 5 9 )
ObsaExpbSMRc95% CIdAEReObsaSMRc95% CIdAEReObsaSMRc95% CIdAERe
Overall13823.55.9 πŸ’ . πŸ— βˆ’ πŸ” . πŸ— βˆ— 5.3845.6 πŸ’ . πŸ“ βˆ’ πŸ” . πŸ— βˆ— 7.154 6.3 πŸ’ . πŸ– βˆ’ πŸ– . πŸ‘ βˆ— 3.8
Type of original cancerγ€€γ€€γ€€γ€€γ€€γ€€γ€€γ€€γ€€γ€€γ€€γ€€γ€€
 Lymphoma465.78 πŸ“ . πŸ— βˆ’ 𝟏 𝟎 . πŸ• βˆ— 7.8276.7 πŸ’ . πŸ’ βˆ’ πŸ— . πŸ• βˆ— 8.719 11.1 πŸ” . πŸ• βˆ’ 𝟏 πŸ• . πŸ’ βˆ— 6.9
 Central nervous system tumor24123.6 𝟏 πŸ“ . 𝟏 βˆ’ πŸ‘ πŸ“ . 𝟏 βˆ— 27.81823.0 𝟏 πŸ‘ . 𝟏 βˆ’ πŸ” . πŸ‘ βˆ— 35.3β€”β€”β€”β€”
 Soft tissue sarcoma111.28.9 πŸ’ . πŸ’ βˆ’ 𝟏 πŸ“ . πŸ– βˆ— 8.9910.7 πŸ’ . πŸ— βˆ’ 𝟐 𝟎 . 𝟐 βˆ— 13.9β€”β€”β€”β€”
 Germ cell tumor94.32.1 𝟏 . 𝟎 βˆ’ πŸ’ . 𝟎 βˆ— 1.692.2 𝟏 . 𝟎 βˆ’ πŸ’ . 𝟐 βˆ— 1.8β€”β€”β€”β€”
 Melanoma163.54.6 𝟐 . πŸ” βˆ’ πŸ• . πŸ’ βˆ— 3.473.5 𝟏 . πŸ’ βˆ’ πŸ• . πŸ‘ βˆ— 3.89 5.9 𝟐 . πŸ• βˆ’ 𝟏 𝟏 . 𝟐 βˆ— 3.2
 Carcinoma (except of skin)216.33.3 𝟐 . 𝟏 βˆ’ πŸ“ . 𝟏 βˆ— 2.283.5 𝟏 . πŸ“ βˆ’ πŸ” . πŸ— βˆ— 4.213 3.2 𝟏 . πŸ• βˆ’ πŸ“ . πŸ“ βˆ— 1.7
 Othersg111.47.73.8–13.87.865.7 𝟐 . 𝟏 βˆ’ 𝟏 𝟐 . πŸ’ βˆ— 7.413 10.6 πŸ“ . πŸ” βˆ’ 𝟏 πŸ– . 𝟏 βˆ— 6.7
Follow-up time (years)　　　　　        
 5–19 years983.527.8 𝟐 𝟐 . πŸ“ βˆ’ πŸ‘ πŸ‘ . πŸ– βˆ— 19.46225.3 𝟏 πŸ— . πŸ’ βˆ’ πŸ‘ 𝟐 . πŸ’ βˆ— 26.136 33.4 𝟐 πŸ‘ . πŸ’ βˆ’ πŸ’ πŸ” . 𝟐 βˆ— 13.5
  Death due to SMN120.335.9 𝟏 πŸ– . πŸ” βˆ’ πŸ” 𝟐 . πŸ– βˆ— 2.4<524.4 πŸ” . πŸ” βˆ’ πŸ” 𝟐 . πŸ‘ βˆ— 1.78 47.1 𝟐 𝟎 . πŸ‘ βˆ’ πŸ— 𝟐 . πŸ— βˆ— 3.0
  Noncancer deaths193.25.9 πŸ‘ . πŸ” βˆ’ πŸ— . πŸ‘ βˆ— 3.214 6.1 πŸ‘ . πŸ‘ βˆ’ 𝟏 𝟎 . πŸ‘ βˆ— 5.15 5.5 𝟏 . πŸ– βˆ’ 𝟏 𝟐 . πŸ— βˆ— 1.6
 20+ years40202 𝟏 . πŸ’ βˆ’ 𝟐 . πŸ• βˆ— 1.222 1.8 𝟏 . 𝟏 βˆ’ 𝟐 . πŸ• βˆ— 1.318 2.4 𝟏 . πŸ’ βˆ’ πŸ‘ . πŸ– βˆ— 1.1
  Death due to SMN114.12.7 𝟏 . πŸ’ βˆ’ πŸ’ . πŸ– βˆ— 0.46 4.0 𝟏 . πŸ“ βˆ’ πŸ– . πŸ• βˆ— 0.65 20.6–4.60.3
  Noncancer deaths1315.90.80.4–1.4βˆ’0.210 0.90.4–1.7βˆ’0.1<50.60.1–1.8βˆ’0.2
Diagnosis periodγ€€γ€€γ€€γ€€γ€€γ€€γ€€γ€€γ€€γ€€γ€€γ€€γ€€
 1970–19797112.75.6 πŸ’ . πŸ’ βˆ’ πŸ• βˆ— 6.0 476.4 πŸ’ . πŸ• βˆ’ πŸ– . πŸ’ βˆ— 10.324 4.5 𝟐 . πŸ— βˆ’ πŸ” . πŸ• βˆ— 3.2
 1980–1989438.74.9 πŸ‘ . πŸ” βˆ’ πŸ” . πŸ• βˆ— 3.8213.4 𝟐 . 𝟏 βˆ’ πŸ“ . 𝟐 βˆ— 3.322 8.7 πŸ“ . πŸ“ βˆ’ 𝟏 πŸ‘ . 𝟐 βˆ— 4.4
 1990–1995242.111.4 πŸ• . πŸ‘ βˆ’ 𝟏 πŸ• βˆ— 7.0 1611.0 πŸ” . πŸ‘ βˆ’ 𝟏 πŸ• . πŸ— βˆ— 9.98 12.3 πŸ“ . πŸ‘ βˆ’ 𝟐 πŸ’ . πŸ‘ βˆ— 4.4
Having chemotherapy　　　　　        
 Yes455.68 πŸ“ . πŸ– βˆ’ 𝟏 𝟎 . πŸ• βˆ— 7.6286.4 πŸ’ . 𝟐 βˆ’ πŸ— . 𝟐 βˆ— 7.717 13.9 πŸ– . 𝟏 βˆ’ 𝟐 𝟐 . 𝟐 βˆ— 7.5
 No7910.87.3 πŸ“ . πŸ– βˆ’ πŸ— . 𝟐 βˆ— 7.1476.7 πŸ’ . πŸ— βˆ’ πŸ– . πŸ— βˆ— 9.0 32 8.6 πŸ“ . πŸ— βˆ’ 𝟏 𝟐 . 𝟐 βˆ— 5.5
 Missing147.22 𝟏 . 𝟏 βˆ’ πŸ‘ . πŸ‘ βˆ— 1.0 92.5 𝟏 . 𝟐 βˆ’ πŸ’ . πŸ– βˆ— 2.45 1.40.5–3.30.3
Having radiationγ€€γ€€γ€€γ€€γ€€γ€€γ€€γ€€γ€€γ€€γ€€γ€€γ€€
 Yes757.99.4 πŸ• . πŸ’ βˆ’ 𝟏 𝟏 . πŸ– βˆ— 10.2468.0 πŸ“ . πŸ— βˆ’ 𝟏 𝟎 . πŸ• βˆ— 11.429 13.1 πŸ– . πŸ– βˆ’ 𝟏 πŸ– . πŸ— βˆ— 8.9
 No6315.64 πŸ‘ . 𝟏 βˆ’ πŸ“ . 𝟐 βˆ— 3.1384.1 𝟐 . πŸ— βˆ’ πŸ“ . πŸ” βˆ— 4.625 4 𝟐 . πŸ” βˆ’ πŸ“ . πŸ— βˆ— 2.1
Having surgery　　　　　        
 Yes8211.67.1 πŸ“ . πŸ” βˆ’ πŸ– . πŸ– βˆ— 6.7496.0 πŸ’ . πŸ“ βˆ’ πŸ– . 𝟎 βˆ— 7.6339.4 πŸ” . πŸ“ βˆ’ 𝟏 πŸ‘ . πŸ‘ βˆ— 5.8
 No424.88.7 πŸ” . πŸ‘ βˆ’ 𝟏 𝟏 . πŸ– βˆ— 8.5267.7 πŸ“ . 𝟎 βˆ’ 𝟏 𝟏 . πŸ‘ βˆ— 10.31611.1 πŸ” . πŸ‘ βˆ’ 𝟏 πŸ– . 𝟎 βˆ— 6.6
 Missing147.12 𝟏 . 𝟏 βˆ’ πŸ‘ . πŸ‘ βˆ— 1.0 92.6 𝟏 . 𝟐 βˆ’ πŸ’ . πŸ– βˆ— 2.551.40.5–3.30.3
Major causes of death (COD)γ€€γ€€γ€€γ€€γ€€γ€€γ€€γ€€γ€€γ€€γ€€γ€€γ€€
 Death due to cancer854.419.3 𝟏 πŸ“ . πŸ’ βˆ’ 𝟐 πŸ‘ . πŸ— βˆ— 3.746 27.6 𝟐 𝟎 . 𝟐 βˆ’ πŸ‘ πŸ” . πŸ— βˆ— 4.539 14.3 𝟏 𝟎 . 𝟏 βˆ’ 𝟏 πŸ— . πŸ“ βˆ— 3.0
  Death due to SMN234.45.2 πŸ‘ . πŸ‘ βˆ’ πŸ• . πŸ– βˆ— 0.910 6.0 𝟐 . πŸ— βˆ’ 𝟏 𝟏 . 𝟏 βˆ— 0.913 4.8 𝟐 . πŸ“ βˆ’ πŸ– . 𝟏 βˆ— 0.9
 Noncancer deaths3219.11.7 𝟏 . 𝟏 βˆ’ 𝟐 . πŸ’ βˆ— 0.624 1.8 𝟏 . 𝟐 βˆ’ 𝟐 . πŸ• βˆ— 1.18 1.40.6–2.70.2
 Missing21N/AN/AN/AN/A14 N/AN/AN/A7 N/AN/AN/A
βˆ— 𝑃 < 0 . 0 5 .
aObs: number of observed deaths.
bExp: number of expected deaths.
cSMR: standardized mortality ratio.
d95% CI: 95% confidence interval.
eAER: absolute excess risk, per 1,000 years at risk.
fTo protect confidentiality, all counts less than five are not specified.
gFor entire cohort and males, other types of original cancers include leukemia, bone tumor, and miscellaneous specified tumor; for females, other types of original cancers include leukemia, CNS, soft tissue sarcoma, germ cell tumor, bone tumor, and miscellaneous-specified tumor.