Research Article

Risk of Late Mortality and Second Malignant Neoplasms among 5-Year Survivors of Young Adult Cancer: A Report of the Childhood, Adolescent, and Young Adult Cancer Survivors Research Program

Table 5

Hazard ratio of SMN.

SMN ( 𝑁 = 6 2 )
Unadjusted HR (95% CI)Adjusted HR (95% CI)

Sexa
 Female11
 Male0.9 (0.5–1.5)0.7 (0.4–1.2)
Type of original cancerb
 Lymphoma11
 Germ cell tumor0.4 (0.2–0.9)*0.5 (0.2–1.1)
 Melanoma 0.3 (0.1–0.7)*0.3 (0.1–0.6)*
 Carcinoma (except of skin)0.3 (0.1–0.5)*0.2 (0.1–0.5)*
 Othersc0.3 (0.1–0.7)*0.3 (0.1–0.7)*
Diagnosis periodd
 1970–197911
 1980–19891.5 (0.8–2.7)1.5 (0.8–2.8)
 1990–19951.8 (0.6–5.1)1.7 (0.6–5)
Relapse < 5 years after diagnosise
 No11
 Yes1.9 (0.8–4.3)1.2 (0.5–2.9)
Having chemotherapyf
 No11
 Yes1.9 (1.1–3.3)*1.3 (0.7–2.5)
Having radiationf
 No11
 Yes2.9 (1.8–4.9)*2.0 (1.1–3.7)*
Having surgeryf
 No11
 Yes0.8 (0.5–1.5)1.4 (0.7–2.7)

𝑃 < 0 . 0 5 .
aMultivariate analyses adjusted for type of original cancer, diagnosis period, and relapse < 5 years after diagnosis.
bMultivariate analyses adjusted for sex, diagnosis period, and relapse < 5 years after diagnosis.
cOther types of original cancers include leukemia, CNS, bone tumor, soft tissue sarcoma, and miscellaneous-specified tumor.
dMultivariate analyses adjusted for sex, type of original cancer, and relapse < 5 years after diagnosis.
eMultivariate analyses adjusted for sex, type of original cancer, and diagnosis period.
fMultivariate analyses adjusted for sex, type of original cancer, diagnosis period, and relapse < 5 years after diagnosis.