Treatment Choices Based on OncotypeDx in the Breast Oncology Care Setting
Table 1
(a) Patient demographic and clinical characteristics by chemotherapy group ()a
Characteristics
Chemotherapy
Total
Yes
No
() (%)
() (%)
() (%)
Demographic
Age in years mean (SD)
56.3 (11.0)
54.1 (10.4)
57.3 (11.1)
.1513
Marital status
.0968
Married/living with partner
83 (70.3)
28 (80.0)
55 (66.3)
Other
33 (28.0)
6 (17.1)
27 (32.5)
Parental status
.6933
Children
85 (72.0)
24 (68.6)
61 (73.5)
No children
28 (23.7)
9 (25.7)
19 (22.9)
Menopause status
.2037
Premenopause
38 (32.2)
14 (40.0)
24 (28.9)
Perimenopause/postmenopause
75 (63.6)
19 (54.3)
56 (67.5)
Race/ethnicity
.6003
White
100 (84.8)
29 (82.9)
71 (85.5)
Other
17 (14.4)
6 (17.1)
11 (13.3)
Family history
.5314
Absent
62 (52.5)
17 (48.6)
45 (54.2)
Present
55 (46.6)
18 (51.4)
37 (44.6)
Clinical
Breast cancer stage
.0595
I
95 (80.5)
25 (71.4)
70 (84.3)
II A
19 (16.1)
8 (22.9)
11 (13.3)
II B
2 (1.7)
0 (0.0)
2 (2.4)
III/III B
2 (1.7)
2 (5.7)
0 (0.0)
Tumor size (mean in cm)
1.6
1.8
1.5
.0694
.5 cm
3 (2.5)
1 (2.9)
2 (2.4)
.0462*
0.6–1.0 cm
22 (18.6)
2 (5.7)
20 (24.1)
1.0 cm
93 (78.8)
32 (91.4)
61 (73.5)
Lymph node
1.0000
Positive
4 (3.4)
1 (2.9)
3 (3.6)
Negative
113 (95.8)
34 (97.1)
79 (95.2)
Histology
.1542
IDC
100 (84.8)
33 (94.3)
67 (80.7)
ILC
7 (5.9)
2 (5.7)
5 (6.0)
Mixed
9 (7.6)
0 (0.0)
9 (10.8)
Other
2 (1.7)
0 (0.0)
2 (2.4)
Histologic grade
.0160*
Low
33 (28.0)
7 (20.0)
26 (31.3)
Intermediate
67 (56.8)
18 (51.4)
49 (59.0)
High
17 (14.4)
10 (28.6)
7 (8.4)
(b) Patient demographic and clinical characteristics by chemotherapy group
Characteristics
Chemotherapy
Total
Yes
No
()
()
()
Nuclear grade
.0004*
1
6 (5.1)
1 (2.9)
5 (6.0)
2
56 (47.5)
8 (22.9)
48 (57.8)
3
24 (20.3)
14 (40.0)
10 (12.1)
HER2
.3598
Positive
6 (5.1)
3 (8.6)
3 (3.6)
Negative
112 (94.9)
32 (91.4)
80 (96.4)
ER
.2966
Positive
117 (99.2)
34 (97.1)
83 (100.0)
Negative
1 (0.9)
1 (2.9)
0 (0.0)
PR
.0560
Positive
105 (89.0)
28 (80.0)
77 (92.8)
Negative
13 (11.0)
7 (20.0)
6 (7.2)
Angiolymphatic invasion
.1092
Absent
86 (72.9)
23 (65.7)
63 (75.9)
Present
20 (17.0)
9 (25.7)
11 (13.3)
Recurrence score (mean)
19.0
26.4
15.9
.0001*
Low
68 (57.6)
4 (11.4)
64 (77.1)
.0001*
Intermediate
37 (31.4)
24 (68.6)
13 (15.7)
High
13 (11.0)
7 (20.0)
6 (7.2)
aPercentages may not total 100 as a result of rounding or missing data, or both.
bA chi-square or Fisher’s exact test was used for categorical variables, and an independent samples -test was used to compare means for the age, tumor size, and recurrence risk score variables.
