Undertreated Breast Cancer in the Elderly

Table 2

Pathologic findings in patients <71 years and ≥71 years.

Pathologic finding	<71 years	≥71 years	𝑃 value
Histopathology
Infiltrating ductal	1408 (68%)	265 (69%)	0.028
Infiltrating lobular	164 (7.9%)	45 (12%)
Ductal carcinoma in situ	424 (21%)	66 (17%)
Unknown	69 (3.3%)	6 (1.6%)
Tumor differentiation
Well	319 (15%)	60 (17%)	0.000
Moderately	855 (41%)	207 (54%)
Poorly	650 (31%)	84 (22%)
Unknown	241 (12%)	31 (8.1%)
Tumor size (cm)*
Median	1.4	1.2	0.015
0–2	1428 (69%)	276 (72%)	0.250
2.1–5	398 (19%)	75 (20%)
>5.1	117 (6%)	14 (3.7%)
Unknown	122 (6%)	17 (4.5%)
Node positive^†	486/1524 (32%)	61/249 (25%)	0.027
Involved nodes^†
Mean	3.9	3.7	0.705
0	1137 (69%)	201 (76%)	0.066
1–3	320 (20%)	37 (14%)
4+	180 (11%)	26 (10%)
Estrogen receptor positive	1314/1702 (77%)	275/321 (86%)	<0.001
Initial resection margin: close/involved	751/1898 (40%)	225/353 (64%)	<0.001
Final Margin: close/involved	134/1863 (7.2%)	43/344 (13%)	0.002
Examined nodes (mean)	6.9	5.7	0.002
Axillary node sampling^†	1524/1572 (97%)	249/310 (80%)	<0.001
Surgery
Breast conservation	1529 (74%)	327 (86%)	<0.001
Mastectomy	519 (25%)	55 (14%)
Unknown	17 (0.8%)	0 (0%)
Neoadjuvant chemotherapy	280/1572 (18%)	20/310 (6.4%)	<0.001
Postoperative chemotherapy	517/1572 (33%)	23/310 (7.2)	<0.001
Tamoxifen/aromatase Inhibitor	1011/1809 (56%)	244/364 (67%)	<0.001
Tamoxifen among estrogen receptor positive patients	912/1217 (75%)	214/273 (78%)	0.231
Radiation therapy	1328/1442 (92%)	184/365 (50%)	<0.001
Radiation therapy in breast conservation	1232/1529 (81%)	173/327 (53%)	<0.001

Data are presented as 𝑛 or 𝑛 (%). (*Size of invasive component. ^†Invasive tumors).