Occupational Exposure to Diesel Motor Exhaust and Lung Cancer: A Dose-Response Relationship Hidden by Asbestos Exposure Adjustment? The ICARE Study
Table 2
OR of lung cancer according to previous occupational exposures and to asbestos.
Cases
Controls
OR1
95% CI
OR2
95% CI
Number
%
Number
%
Total
2264
2780
Ever worked in List A industries/occupations
No
1824
80.6
2451
88.2
1.00
[ref]
Yes
440
19.4
329
11.8
1.78
1.52–2.08
Cumulative exposure of asbestos (sensitive definition)3
Not exposed
638
28.6
1147
41.5
1.00
[ref]
1.00
[ref]
]0–0.27], low level
613
27.5
808
29.2
1.49
1.25–1.79
1.45
1.21–1.74
]0.27–14], medium level
691
31.0
648
23.5
1.71
1.43–2.05
1.61
1.33–1.94
>14, high level
285
12.8
159
5.8
2.49
1.91–3.25
2.29
1.74–3.02
Test for trend,
<10−4
<10−4
Cumulative exposure of asbestos (specific definition)4
Not exposed
1189
52.8
1823
65.6
1.00
[ref]
1.00
[ref]
]0–1.63], low level
428
19.0
477
17.2
1.30
1.25–1.79
1.22
1.01–1.47
]1.63–24], medium level
460
20.4
383
13.8
1.53
1.43–2.05
1.41
1.15–1.72
>24, high level
173
7.7
96
3.5
1.88
1.91–3.25
1.70
1.23–2.35
Test for trend,
<10−4
OR: odds ratio; CI: confidence interval; CSI: comprehensive smoking index (see Section 2.7). 1: adjusted for age, département, and CSI. 2: adjusted for age, département, CSI, and List A job. 3: This definition takes into account all job periods, whatever the proportion of workers potentially exposed to asbestos in the job (i.e., sensitive definition) (see Section 2.6). 4: This definition takes into account job periods whose proportion of workers potentially exposed to asbestos is above 30% (i.e., specific definition) (see Section 2.6).
