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E-Journal of Chemistry
Volume 9 (2012), Issue 4, Pages 1801-1809
http://dx.doi.org/10.1155/2012/458035

Synthesis, Anti-Bacterial and Anti-Fungal Evaluation of Pyrazoline Derivatives

Industrial Chemistry Department, V.P. & R.P.T.P. Science College, Vallabh Vidyangar-388120, Gujarat, India

Received 23 September 2011; Accepted 25 December 2011

Copyright © 2012 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The Series of N-(5-(Substituted phenyl)-4,5-dihydro-1H-pyrazol-3-yl)-4H-1,2,4-triazol-4-amine compounds were prepared by reaction of 4-amino-1,2,4-Triazole with Acetyl Chloride followed by different aromatic aldehydes and cyclization with hydrazine hydrate. The structures of new compounds were confirmed by IR and 1H-NMR spectral data. Anti-bacterial and Anti-fungal activities were evaluated and compared with the standard drugs, some compounds of the series exhibited promising anti-microbial and anti-fungal activity compared to standard drugs.