“On Water” Sonochemical Multicomponent Synthesis of Novel Bioactive 1,1′-(Aryl)bis(2-(cyclohexylamino)-2-oxoethane-1,1-diyl) Di(alkanoates and benzoates)

Mamaghani, Manouchehr; Mahmoodi, Nosrat O.; Shirini, Farhad; Azimi-Roshan, Abbas; Monfared, Azam

doi:https://doi.org/10.1155/2013/125959

Journal of Chemistry

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Abstract Introduction Experimental Results and Discussion Conclusions Acknowledgments References Copyright Related Articles

Research Article | Open Access

Volume 2013 | Article ID 125959 | https://doi.org/10.1155/2013/125959

“On Water” Sonochemical Multicomponent Synthesis of Novel Bioactive 1,1′-(Aryl)bis(2-(cyclohexylamino)-2-oxoethane-1,1-diyl) Di(alkanoates and benzoates)

Manouchehr Mamaghani,¹Nosrat O. Mahmoodi,¹Farhad Shirini,¹Abbas Azimi-Roshan,¹and Azam Monfared²

Academic Editor: Marijan Kocevar

Received19 May 2013

Revised09 Sept 2013

Accepted30 Sept 2013

Published29 Dec 2013

Abstract

An expeditious, efficient, and ecofriendly ultrasound-promoted synthesis of a series of novel 1,1′-(aryl)bis(2-(cyclohexylamino)-2-oxoethane-1,1-diyl) di(alkanoate and benzoate) derivatives (6a–k), as useful building block candidates for natural products and drugs, is reported. The target compounds were prepared by the reaction of alkyl or aryl carboxylic acid, various bisaldehydes and isocyanocyclohexane in water using one-pot isocyanide-based multicomponent approach. This efficient protocol without using any catalyst furnished the products in short reaction times (4-5 min) and excellent yields (87–96%). The antibacterial activity of the selected products was also examined. Some products showed promising activities.

1. Introduction

Organic transformations in aqueous solvents are not new to organic chemists; the earliest example dated back to 1882 when Baeyer and Drewsen reported the synthesis of indigo in aqueous acetone [1]. Water possesses many unique physical and chemical properties, and considerable rate acceleration is often observed in reactions carried out under on water conditions over those in organic solvents [2, 3]. These specified properties are the consequence of the unique structure of water [4, 5]. Considerable efforts have been directed at understanding the physical nature of the rate acceleration of water-based reactions. Possible source of rate increase such as hydrophobic hydration offering more favorable environment for the transition state (TS) relative to the reactants enhanced H-bonding in the transition state compared to that in the reactants; high cohesive energy density of water and enforced hydrophobic interactions have been emphasized [6]. The use of water as a solvent for organic transformations offers several “green chemistry” benefits [7]. Other advantages of on water reactions include the safety and almost zero cost of water relative to organic solvents and the ease of product isolation. A significant example of an on water accelerated cycloaddition reaction between quadricyclane and dimethyl azodicarboxylate was described by Narayan and coworkers. This reaction took 10 min (on water) and 5 days (in toluene) to reach completion [8]. In addition to the rate acceleration or increase in yields, high stereo- and regioselectivity were also obtained for asymmetric aldol reactions and certain Diels-Alder reactions by performing emulsion reactions on water [6].

On the other hand, MCRs are by far the most versatile reactions in terms of scaffolds and number of accessible compounds and have gained prominence with the advent of combinatorial chemistry and related library-synthesis strategies in the last two decades [9–12]. In particular isocyanide-based multicomponent reactions (IMCRs) have been of particular interest due to their wide applications in the synthesis of natural products, lead compounds in the drug discovery process, and other targets of interest [13–19]. Among the isocyanide-based multicomponent reactions, the Passerini reaction is the most important one which incorporates every atom in the starting material in the product. Consequently, there is no intrinsic chemical waste associated with the reaction, therefore achieving 100% atom economy [20, 21].

Recently, the use of ultrasonic irradiation as clean, green, and environmentally benign route to activate organic reactions has attained greater value, compared to conventional heating. It has been used for a wide variety of organic reactions, such as sterically congested Passerini reactions [22], oxidations, reductions, cleavage of epoxides, multicomponent reactions, synthesis of ionic liquids, and N-heterocyclic compounds [23–25].

In this report, we have used Passerini reaction for isocyanide-based multicomponent synthesis of novel 1,1′-(aryl)bis(2-(cyclohexylamino)-2-oxoethane-1,1-diyl) di(alkanoate and benzoate) derivatives under ultrasonic irradiation and without catalyst, performed on water under the conditions defined by Narayan and coworkers [3, 8].

2. Experimental

2.1. General

For the ultrasound reactions, ultrasound apparatus Astra 3D (9.5 L, 45 kHz frequency, input power with heating, 305 W, number of transducers, 2) from TECNO-GAZ was used. Melting points were measured on an Electrothermal 9100 apparatus. FT-IR spectra were determined on a Shimadzo FT-IR spectrometer. ¹H NMR and ¹³C NMR spectra were recorded on a 400 or 500 MHz Bruker DRX-400 in CDCl₃ or DMSO-d₆ as solvent and TMS as an internal standard. Elemental analyses were done on a Carlo-Erba EA1110 CNOS analyzer and agreed with the calculated values. Chemicals were purchased from Merck and Aldrich. All solvents used were dried and distilled according to the standard procedures.

2.2. Synthesis of 6a–k

A mixture of alkyl and aryl carboxylic acid (5a–h) (1.0 mmol), cyclohexyl isocyanide (3) (1.0 mmol, 0.109 g), bisaldehydes (4a–c) (0.5 mmol), and H₂O (5 mL) were placed into Pyrex glass open vessel and irradiated in a water bath under silent condition by ultrasound (45 kHz) at room temperature for the required reaction times. Initially the reaction occurred under heterogeneous condition, and the solid product thus formed was isolated by filtration, washed with 3 × 1 mL of 10% NaHCO₃ and 2 × 1 mL water, and dried under high vacuum. The product was recrystallized from ethanol to produce 1,1′-(aryl)bis(2-(cyclohexylamino)-2-oxoethane-1,1-diyl) di(alkanoate and benzoate) derivatives (6a–k) as pure crystalline products in 87–96% yields (Table 2).

2.2.1. 6a: White Solid

Mp 212–214°C; FT-IR (KBr, cm⁻¹) 3295, 3070, 2920, 2845, 1735, 1655, 1540, 1055; ¹H NMR (400 MHz, CDCl₃) : 1.18 (6H, m), 1.36 (4H, m), 1.69 (8H, m), 1.92 (4H, d, br., = 15.4 Hz), 2.19 (4H, s), 3.78 (2H, m), 6.02 (2H, d, = 8.8 Hz, NH), 6.05 (2H, s), 7.43 (4H, s); ¹³C NMR (100 MHz, CDCl₃) : 21.1, 24.8, 25.4, 32.9, 33.0, 48.3, 75.0, 127.8, 136.5, 166.9, 169.0; Anal. Calcd. for C₂₆H₃₆N₂O₆: C, 66.08; H, 7.68; N, 5.93. Found: C, 66.16; H, 7.76; N, 6.05.

2.2.2. 6b: White Solid

Mp 232-233°C; FT-IR (KBr, cm⁻¹) 3300, 3080, 2920, 2850, 1745, 1660, 1540, 1080; ¹H NMR (400 MHz, CDCl₃) : 1.16 (4H, m), 1.20 (6H, m), 1.37 (4H, m), 1.63 (4H, m), 1.72 (4H, d, br., = 13.2 Hz), 1.91 (4H, d, br., = 11.6 Hz), 2.47 (4H, m), 3.79 (2H, m), 6.02 (2H, d, = 6.4 Hz, NH), 6.07 (2H, s), 7.43 (4H, s); ¹³C NMR (100 MHz, CDCl₃) : 9.0, 24.7, 25.4, 27.6, 32.9, 33.0, 48.2, 74.8, 127.7, 136.5, 167.1, 172.4; Anal. Calcd. for C₂₈H₄₀N₂O₆: C, 67.05; H, 8.05; N, 5.60. Found: C, 67.14; H, 7.98; N, 5.71.

2.2.3. 6c: White Solid

Mp 212–214°C; FT-IR (KBr, cm⁻¹) 3300, 3080, 2925, 2845, 1745, 1660, 1545, 1140; ¹H NMR (400 MHz, CDCl₃) : 1.00 (6H, m), 1.17 (6H, m), 1.38 (4H, m), 1.62 (2H, s), 1.72 (8H, m), 1.92 (4H, d, br., = 10.8 Hz), 2.43 (4H, m), 3.80 (2H, m), 6.01 (2H, d, br., = 6.4 Hz, NH), 6.08 (2H, s), 7.43 (4H, s); ¹³C NMR (100 MHz, CDCl₃) : 13.6, 18.4, 24.7, 25.4, 32.9, 33.0, 36.1, 48.2, 74.7, 127.7, 136.5, 167.1, 171.6; Anal. Calcd. for C₃₀H₄₄N₂O₆: C, 68.15; H, 8.39; N, 5.30. Found: C, 68.10; H, 8.48; N, 5.37.

2.2.4. 6d: White Solid

Mp 214-215°C; FT-IR (KBr, cm⁻¹) 3290, 3080, 2940, 2845, 1730, 1660, 1540, 1160; ¹H NMR (500 MHz, DMSO-d₆) : 1.11 (6H, m), 1.22 (6H, m), 1.29 (6H, m), 1.54 (8H, s), 1.59 (4H, m), 1.70 (4H, m), 2.40 (4H, m), 3.46 (2H, s), 5.81 (2H, s), 7.44 (4H, s), 8.10 (2H, d, = 8.0 Hz, NH); ¹³C NMR (100 MHz, DMSO-d₆) : 14.1, 22.0, 24.9, 24.94, 25.6, 26.9, 32.5, 32.6, 33.5, 48.1, 74.9, 127.6, 136.8, 167.2, 172.6; Anal. Calcd. for C₃₂H₄₈N₂O₆: C, 69.03; H, 8.68; N, 5.03. Found: C, 68.83; H, 8.59; N, 5.22.

2.2.5. 6e: White Solid

Mp 179-180°C; FT-IR (KBr, cm⁻¹) 3270, 3100, 2920, 2840, 1730, 1655, 1560, 1110; ¹H NMR (400 MHz, DMSO-d₆) : 1.15 (8H, m), 1.54 (8H, m), 1.68 (2H, s), 1.77 (2H, s), 3.49 (2H, s), 6.08 (2H, s), 7.57 (6H, m), 7.64 (4H, s), 7.71 (2H, quint., = 6.8 Hz), 7.83 (2H, d, = 8.0 Hz, NH), 8.06 (4H, t, = 8.0, 7.2 Hz); ¹³C NMR (100 MHz, DMSO-d₆) : 24.8, 24.9, 25.6, 32.5, 32.7, 48.2, 75.7, 127.7, 127.74, 128.0, 129.3, 129.6, 129.9, 130.1, 134.1, 136.8, 165.4, 167.1; Anal. Calcd. for C₃₆H₄₀N₂O₆: C, 72.46; H, 6.76; N, 4.69. Found: C, 72.58; H, 6.69; N, 4.75.

2.2.6. 6f: White Solid

Mp 203–205°C; FT-IR (KBr, cm⁻¹) 3295, 3080, 2925, 2845, 1730, 1665, 1545, 1075; ¹H NMR (400 MHz, DMSO-d₆) : 1.10 (4H, m), 1.20 (6H, m), 1.54 (6H, m), 1.72 (4H, m), 2.53 (6H, s), 3.50 (2H, s), 6.06 (2H, s), 7.32 (2H, d, = 6.8 Hz), 7.34 (2H, d, = 5.6 Hz, NH), 7.50 (2H, quint., = 1.2, 7.6 Hz), 7.61 (4H, s), 7.94 (2H, t, = 3.6, 8.0 Hz), 8.26 (2H, d, = 7.2 Hz); ¹³C NMR (100 MHz, DMSO-d₆) : 21.5, 24.8, 24.9, 25.6, 32.5, 32.6, 48.2, 75.8, 126.5, 127.8, 129.4, 130.9, 132.1, 132.9, 136.7, 139.8, 166.5, 167.2; Anal. Calcd. for C₃₈H₄₄N₂O₆: C, 73.05; H, 7.10; N, 4.48. Found: C, 73.17; H, 7.16; N, 4.45.

2.2.7. 6g: White Solid

Mp 171-172°C; FT-IR (KBr, cm⁻¹) 3300, 3055, 2945, 2865, 1745, 1660, 1555, 1110; ¹H NMR (400 MHz, DMSO-d₆) : 1.20 (10H, m), 1.55 (6H, m), 1.72 (4H, m), 3.52 (2H, s), 6.07 (2H, s), 7.50 (2H, m), 7.62 (8H, m), 7.96 (2H, dt, = 7.2, 0.8 Hz), 8.28 (2H, d, = 7.6 Hz); ¹³C NMR (100 MHz, DMSO-d₆) : 24.8, 24.9, 25.6, 32.5, 32.6, 48.2, 76.3, 127.8, 127.9, 127.92, 129.5, 131.4, 132.2, 132.8, 134.1, 136.4, 164.4, 166.8; MS (EI, 70 eV): m/z (%) = 666 (0.58) [M^+●+2], 664 (0.9) [M^+●], 274 (34), 156 (19), 141 (36), 140 (14), 139 (100) [C₇H₄ClO], 113 (11), 111 (26) [C₆H₄Cl], 97 (13), 83 (18). Anal. Calcd. for C₃₆H₃₈Cl₂N₂O₆: C, 64.96; H, 5.75; N, 4.21. Found: C, 64.85; H, 5.81; N, 4.26.

2.2.8. 6h: White Solid

Mp 222–224°C; FT-IR (KBr, cm⁻¹) 3257, 3079, 2929, 2855, 1723, 1670, 1564, 1109; ¹H NMR (500 MHz, CDCl₃) : 1.14 (6H, m), 1.33 (4H, m), 1.62 (6H, m), 1.90 (4H, m), 3.79 (2H, quint., = 3.65 Hz), 5.98 (2H, t, = 8.28 Hz), 6.31 (2H, d, = 8.32 Hz, NH), 7.46 (5H, m), 7.55 (2H, m), 7.61 (2H, m), 7.69 (1H, s), 8.08 (4H, d, = 7.54 Hz); ¹³C NMR (100 MHz, DMSO-d₆) : 24.8, 24.9, 25.0, 25.7, 32.4, 32.5, 32.7, 48.1, 48.2, 75.7, 75.8, 125.6, 126.1, 127.6, 128.1, 129.0, 129.1, 129.2, 129.3, 129.7, 129.9, 130.0, 134.1, 136.8, 136.9, 165.3, 165.4, 167.0, 167.1; Anal. Calcd. for C₃₆H₄₀N₂O₆: C, 72.46; H, 6.76; N, 4.69. Found: C, 72.60; H, 6.82; N, 4.66.

2.2.9. 6i: Light Yellow Solid

Mp 154-155°C; FT-IR (KBr, cm⁻¹) 3274, 3087, 2929, 2856, 1734, 1661, 1538, 1483, 1347, 1136; ¹H NMR (500 MHz, CDCl₃) : 0.96 (4H, m), 1.11 (6H, m), 1.46 (4H, m), 1.58 (4H, m), 1.78 (2H, d, br., = 11.38 Hz), 3.57 (2H, s), 6.15 (2H, s), 6.95 (2H, s, br., NH), 7.33 (1H, t, = 9.39 Hz), 7.50 (2H, d, = 8.0 Hz), 7.55 (2H, t, = 8.16 Hz), 7.72 (1H, s), 8.31 (4H, t, = 9.26 Hz), 8.75 (2H, s); ¹³C NMR (100 MHz, DMSO-d₆) : 24.8, 24.9, 25.5, 32.4, 32.7, 48.2, 76.4, 124.3, 126.0, 128.2, 128.6, 129.2, 131.2, 131.3, 136.0, 136.5, 148.4, 163.8, 166.7; Anal. Calcd. for C₃₆H₃₈N₄O₁₀: C, 62.96; H, 5.58; N, 8.16. Found: C, 62.81; H, 5.64; N, 8.23.

2.2.10. 6j: White Solid

Mp 185–187°C; FT-IR (KBr, cm⁻¹) 3248, 3076, 2925, 2855, 1721, 1658, 1559, 1057; ¹H NMR (400 MHz, DMSO-d₆) : 1.09 (4H, m), 1.20 (6H, m), 1.53 (6H, m), 1.72 (4H, m), 2.52 (6H, s), 3.50 (2H, s), 6.08 (2H, d, = 3.6 Hz), 7.30 (2H, d, = 7.6 Hz, NH), 7.33 (2H, d, = 7.2 Hz), 7.46 (1H, m), 7.51 (2H, m), 7.57 (2H, d, = 8.4 Hz), 7.78 (1H, s), 7.78 (1H, s), 7.94 (2H, dd, = 7.6, 1.2 Hz), 8.27 (1H, d, = 8.0), 8.29 (1H, = 8.0 Hz); ¹³C NMR (100 MHz, DMSO-d₆) : 21.5, 21.54, 24.8, 24.88, 24.9, 25.6, 32.5, 32.7,48.1, 48.2, 75.8, 126.0, 126.3, 126.4, 128.0, 128.2, 128.94, 129.0, 129.5, 130.8, 130.9, 132.1, 132.9, 136.8, 139.8, 139.9, 166.5, 166.6, 167.0, 167.1; Anal. Calcd. for C₃₈H₄₄N₂O₆: C, 73.05; H, 7.10; N, 4.48. Found: C, 73.16; H, 7.02; N, 4.43.

2.2.11. 6k: White Solid

Mp 183–185°C; FT-IR (KBr, cm⁻¹) 3416, 3067, 2933, 2861, 1717, 1678, 1595, 1100; ¹H NMR (500 MHz, CDCl₃) : 1.14 (6H, m), 1.32 (4H, m), 1.56 (6H, m), 1.65 (2H, m), 1.66 (2H, m), 1.87 (2H, m), 2.03 (2H, m), 3.79 (2H, m), 4.08 (2H, m), 4.15 (2H, m), 6.15 (2H, d, = 8.14, NH), 6.66 (2H, s), 6.91 (2H, m), 7.00 (2H, m), 7.33 (2H, m), 7.43 (4H, m), 7.55 (4H, m), 8.08 (4H, m); ¹³C NMR (100 MHz, DMSO-d₆) : 25.0, 25.1, 25.5, 25.6, 32.6, 48.3, 67.6, 71.0, 112.5, 120.8, 124.5, 124.6, 128.8, 129.2, 129.8, 129.9, 130.7, 133.9, 157.1, 165.5, 167.0; Anal. Calcd. for C₄₆H₅₂N₂O₈: C, 72.61; H, 6.89; N, 3.68. Found: C, 72.75; H, 6.97; N, 3.62.

2.3. Determination of Antimicrobial Activity

A sterilized glass tube (5 mm diameter) was used aseptically to make wells on plates. The antibacterial activity of compounds was assayed biologically using the agar well-diffusion method. A colony of each standard test organism was subcultured in order to obtain fresh bacteria on the nutrient agar plates at 37°C for 18 h. For preparation of suspensions of microorganisms (0.5 McFarland), one to two colonies from each plate were dissolved in isotonic saline solution. Then Mueller-Hinton agar (Merck) plates were prepared according to manufacturers’ instructions in order to evaluate the antibacterial activities of compounds. The sterile Mueller-Hinton agar plates were inoculated with the bacteria. 0.01 gram of test samples was dissolved in 1 mL dimethyl sulfoxide (DMSO) to obtain a stock solution. A concentration of 1 mg/mL or 100 μg/0.1 mL of each sample was prepared. 0.1 mL of prepared samples was dropped into each respective labeled well aseptically. The inoculated plates were left on the table for 1 h to allow each sample to diffuse into the agar. For comparison, gentamycin was used as a positive control and DMSO as a negative control. Test organism growth may be affected by the inhibitory action of the test compound, and so a clear zone around the disc appeared as an indication of the inhibition of the test organism growth. The results of our tests were presented as the inhibition zones, given in millimeters (mm). Measurements were obtained after 24 h for bacteria.

3. Results and Discussion

In recent years due to emergence of green chemistry, removing organic solvents has become an important factor towards developing benign chemical technologies due to their high toxicity [26]. As a result, organic reactions in aqueous media have gained high priority in view of green methodology and have been regularly reviewed in the literature [3, 27–32].

We verified the effect of various solvents on the efficiency of the reaction by using synthesis of 6a as model reaction. The reaction proceeded best under aqueous condition as shown in Table 1, and none of the conventional organic solvents such as CH₃CN, 1,4-dioxane, CH₂Cl₂, and DMF proved satisfactory, and this may be due to unique properties of water.

In continuation of our efforts for developing benign synthetic methodologies for the production of various biologically important products [33–36], we wish to report a versatile and efficient isocyanide-based multicomponent one-pot synthesis of 1,1′-(aryl)bis(2-(cyclohexylamino)-2-oxoethane-1,1-diyl) di(alkanoate and benzoate) derivatives (6a–k) utilizing the reaction of alkyl and aryl carboxylic acids (5a–h) (1 mmol), isocyanocyclohexane (3) (1 mmol), and bisaldehydes (4a–c) (0.5 mmol) (Figure 1) in water under ultrasonic irradiation (Scheme 1). This rapid method produced the products in short reaction times (4-5 min) and excellent yields (87–96%) (Table 2). The structures of the products were deduced from their elemental analyses and spectroscopic data.

In this study, because of the presence of the chiral carbon in the molecules, despite the symmetry of the molecules, in the ¹³C NMR spectrum, a number of cyclohexyl carbons appeared as two distinct peaks at the region of 24–33 ppm. It is worth noting that ¹H NMR and FT-IR spectra as well as elemental analysis all confirmed the structure of the 1,1′-(aryl)bis(2-(cyclohexylamino)-2-oxoethane-1,1-diyl) di(alkanoate and benzoate) derivatives (6a–k).

A plausible mechanism for the formation of the products (6a–k) can be visualized in Scheme 2.

The in vitro antibacterial activities of compounds 6a–k were evaluated against gram-positive and gram-negative bacteria using the cultures of three different standard microorganisms: Acinetobacter calcoaceticus ATCC 23055 and Pseudomonas aeruginosa ATCC 9027 as gram-negative models and Bacillus subtilis ATCC 6633 as a gram-positive model. Compounds 6a–c and 6h–j exhibited good antibacterial activity against Pseudomonas aeruginosa that may be due to the incorporation of amide and carbonyl groups. Also the results indicate that compounds 6a, 6b, 6d, 6j, and 6k have moderate and 6f hasa good growth-inhibiting activity against Bacillus subtilis. Among these substances, 6a–c, 6g, and 6k show low growth-inhibiting effects on Acinetobacter calcoaceticus. The results are shown in Table 2.

4. Conclusions

In summary, we have developed an expeditious and efficient protocol for the synthesis of novel 1,1′-(aryl)bis(2-(cyclohexylamino)-2-oxoethane-1,1-diyl) di(alkanoate and benzoate) derivatives (6a–k) via the reaction of alkyl and aryl carboxylic acids, various bisaldehydes, and isocyanocyclohexane in water under ultrasonic irradiation using one-pot three-component approach. The reaction gives excellent yields (87–96%) of the products in short reaction times (4-5 min). The reaction is clean and highly expeditious, involves water as the green solvent, and occurs at ambient conditions. The protocol does not involve the use of catalyst and tedious workup procedure and thus is an environmentally friendly process. Some of the compounds prepared as part of this study exhibited good antibacterial activity against Pseudomonas aeruginosa.

Conflict of Interests

The authors declare that there is no conflict of interests.

Acknowledgments

The authors thank the Research Committee of University of Guilan for the partial support of this study.

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Copyright © 2013 Manouchehr Mamaghani et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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