Synthesis and Antimicrobial and Antioxidant Activities of Some New 5-(2-Methyl-1H-indol-3-yl)-1,3,4-oxadiazol-2-amine Derivatives

Table 1

Antimicrobial activities of the compounds (1 and 3–5).

Compound no.	R	R′	Diameter of zone of inhibition in mm^#
			Antibacterial activity			Antifungal activity
			E. coli	B. subtilis	K. pneumonia	A. niger	A. flavus	A. fumigates
1	—	—	14±1.63	12±1.31	14±1.88	17±1.60	14±1.76	11±1.81
3a	Cl	—	10±2.29	14±1.27	06±1.93	09±1.41	12±1.06	13±1.68
3b	CH3	—	05±1.83	09±1.25	13±1.85	08±0.67	11±1.60	18±1.43
3c	H	—	02±1.01	07±1.06	12±1.35	00±0.00	05±1.35	03±1.81
4a	Cl	—	14±2.00	14±1.72	10±2.80	18±1.82	13±1.82	08±2.00
4b	CH3	—	06±1.43	03±1.39	15±2.25	08±1.96	19±2.16	07±1.76
4c	H	—	10±2.05	09±1.02	07±1.54	06±1.49	04±1.47	09±1.76
5a	Cl	Ph	03±1.57	14±1.73	04±1.51	12±1.88	19±0.94	17±1.72
5b	CH3	Ph	13±2.15	10±1.56	05±1.61	05±1.39	01±0.76	13±1.68
5c	H	Ph	07±1.24	11±1.49	12±1.96	9±1.92	14±1.48	12±0.91
5d	Cl	Cl	16±2.23	15±2.16	15±1.96	19±1.72	20±1.68	18±1.49
5e	CH3	Cl	02±1.23	08±1.15	05±1.48	07±1.72	05±1.68	17±1.50
5f	H	Cl	10±1.60	14±1.35	07±1.28	12±0.95	15±1.12	08±1.39
Std-1	—	—	17±1.80	16±1.92	16±2.29	—	—	—
Std-2	—	—	—	—	—	20±1.61	22±1.61	19±1.81

Including diameter of well^#, control (DMF) = no activity, Std-1 = streptomycin, Std-2 = fluconazole.