Review Article
An Overview of Analytical Determination of Diltiazem, Cimetidine, Ranitidine, and Famotidine by UV Spectrophotometry and HPLC Technique
Table 4
Application of HPLC to the simultaneous determination of H2 receptor antagonists.
| Column | Mobile phase | Detection (nm) | Ref. |
| RP-mediterranea column C18 (250 × 4.6 mm, 5 μm) | ACN : methanol : water (20 : 28 : 52 v/v/v) pH 2.8 adjusted by phosphoric acid | 221, 256 and 267 | [211] | Hypersil, ODS, C18 (150 9 4.6 mm, 5 lm) and Purospher_STAR RP-18 column | ACN : water (70 : 25 v/v) pH adjusted to 3.0 by phosphoric acid | 225 | [212] | Purospher star C18 (5 μm, 25 × 0.46 cm) column | methanol : water (60 : 40 v/v), pH adjusted to 3.0 ± 0.02 by phosphoric acid | 225 | [213] | Purospher Star RP18 endcapped (250 mm × 4.6 mm I.D.) column packed with 5-μm particles. | Methanol-water-triethylamine (20 : 80 : 0.05), whose pH was adjusted to 3.0 with phosphoric acid | 229 | [214] | Nucleosil, 100-10, C-18 column (250 × 4.6 mm, 10 micron) | Methanol : water : acetonitrile (60 : 45 : 5 v/v, pH 3.83) | 240 | [215] | Purospher STAR C18 (250 × 4.6 mm, 5 μm) column | Methanol : water : ACN (54 : 41 : 5 v/v/v) pH 2.7 adjusted by phosphoric acid | 232 and 250 | [216] | (15 cm × 4.6 mm ID) of Inertsil ODS-2 (5 μm) column | 0.04 M aqueous sodium dihydrogen phosphate : ACN : methanol : TEA (345 : 20 : 35 : 0.7 v/v/v/v) | 230 nm | [217] |
|
|