Genistein Derivatives Regioisomerically Substituted at 7-O- and 4′-O- Have Different Effect on the Cell Cycle

<table>ATM activation in HCT 116 wt cells treated with genistein (100 <i>μ</i>M), camptothecin CPT (1 <i>μ</i>M), and genistein derivatives substituted at C4′ at the concentration equivalent to 3x IC<sub>50</sub> (Ram-2′ (3 <i>μ</i>M), Ram-3′ (40 <i>μ</i>M), Ram-5′ (20 <i>μ</i>M), Gen-5′ (20 <i>μ</i>M). HSC 70 served as a loading control.</table>

Journal of Chemistry

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Figure 7

Figure 7: Genistein Derivatives Regioisomerically Substituted at 7-O- and 4′-O- Have Different Effect on the Cell Cycle 