Genistein Derivatives Regioisomerically Substituted at 7-O- and 4′-O- Have Different Effect on the Cell Cycle

<table>The level of total p53, phosphorylated p53 (ser 15), p21 and MDM2 in HCT 116 wt cells treated for 24 h with the tested genistein derivatives used at the concentration equivalent to 3x IC<sub>50</sub> (Ram-2′ (3 <i>μ</i>M), Ram-3′ (40 <i>μ</i>M), Ram-5′ (20 <i>μ</i>M), Gen-5′ (20 <i>μ</i>M). Genistein (Genist) and camptothecin (CPT) were used as positive controls. HSC 70 served as a loading control.</table>

Journal of Chemistry

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Figure 8

Figure 8: Genistein Derivatives Regioisomerically Substituted at 7-O- and 4′-O- Have Different Effect on the Cell Cycle 