Table 1: Specific rates of solvolysis (k) of 6 and 7 in several binary solvents at 25.0°C and literature values for 𝑁 𝑇 and 𝑌 C l .

Solvent ( % ) a (6 @ 25.0°C; 105 k , s-1) b (7 @ 25.0°C; 105 k , s-1) b 𝑁 𝑇 c 𝑌 d C l

100% MeOH11.3 ± 0.929.9 ± 2.20.17−1.2
90% MeOH22.5 ± 1.547.9 ± 1.6−0.01−0.20
80% MeOH30.1 ± 1.664.5 ± 1.1−0.060.67
100% EtOH1.51 ± 0.1715.9 ± 1.00.37−2.50
90% EtOH3.02 ± 0.2426.4 ± 1.10.16−0.90
80% EtOH4.30 ± 0.1239.6 ± 0.80.000.00
70% EtOH6.64 ± 0.19−0.200.80
90% Acetone0.327 ± 0.0180.870 ± 0.015−0.35−2.39
80% Acetone0.577 ± 0.0291.85 ± 0.25−0.37−0.80
70% Acetone0.980 ± 0.0262.78 ± 0.16−0.420.17
97% TFE (w/w)1.07 ± 0.070.0456 ± 0.0012−3.302.83
90% TFE (w/w)1.49 ± 0.170.354 ± 0.024−2.552.85
80% TFE (w/w)2.12 ± 0.12−2.222.90
50% TFE (w/w)1.88 ± 0.17−1.733.16
80T-20E0.399 ± 0.0120.332 ± 0.015−1.761.89
60T-40E0.626 ± 0.0091.03 ± 0.04−0.940.63
40T-60E1.16 ± 0.053.26 ± 0.15−0.340.48
20T-40E2.34 ± 0.1210.6 ± 0.40.08−1.42
97% HFIP (w/w)24.3 ± 1.21.92 ± 0.06−5.265.17
90% HFIP (w/w)23.0 ± 0.91.39 ± 0.13−3.844.31
70% HFIP (w/w)18.2 ± 1.3−2.943.83
50% HFIP (w/w)0.888 ± 0.015−2.493.80

a S ubstrate concentration of ca. 0.0052 M; binary solvents on a volume-volume basis at 25.0°C, except for TFE-H2O and HFIP-H2O solvents which are on a weight-weight basis. T-E are TFE-ethanol mixtures. b W ith associated standard deviation. c R eferences [19, 20]. d R eferences [2123].