Synthesis and Antifungal Studies of (2E)-N-Benzyl-N′-phenylbut-2-enediamide and (2E)-N,N′-Dibenzylbut-2-enediamide Analogues

Table 1

Antifungal activity of the synthesised butenediamides (MIC) μM.

Compound	C. albicans (ATCC90028)	C. albicans (ATCC10231)	C. krusei (ATCC6258)	C. parapsilosis (ATCC22019)
3a	44.6 ± 0.57	44.6 ± 1.21	178.5 ± 0.36	44.6 ± 0.46
3b	—	—	—	—
3c	40.3 ± 0.48	80.6 ± 0.42	161.2 ± 1.61	20.2 ± 0.39
3d	159.2 ± 0.45	159.2 ± 0.60	159.2 ± 0.51	159.2 ± 0.41
3e	636.8 ± 0.64	636.8 ± 2.55	159.2 ± 0.80	159.2 ± 1.43
3f	—	—	615.2 ± 0.65	615.2 ± 1.54
3g	307.6 ± 0.31	307.6 ± 0.77	307.6 ± 0.40	153.8 ± 2.21
3h	355.7 ± 1.78	355.7 ± 0.75	177.9 ± 0.60	355.7 ± 0.89
3i	170.0 ± 0.44	170.0 ± 0.41	170.0 ± 1.16	170.0 ± 0.61
3j	320.4 ± 0.54	320.4 ± 0.51	640.8 ± 1.60	640.8 ± 1.60
3k	640.8 ± 1.12	640.8 ± 0.80	640.8 ± 0.74	640.8 ± 0.51
Amphotericin-B	1.3 ± 0.60	1.3 ± 0.49	5.4 ± 0.54	1.3 ± 0.27

All experiments were carried out in triplicate. Data reported as the mean of three experiments.
Key: —: No activity.