Research Article
Sparfloxacin-Metal Complexes as Urease Inhibitors: Their Synthesis, Characterization, Antimicrobial, and Antienzymatic Evaluation
Table 6
(a) Inhibition zones (mm) against C. albicans. (b) Inhibition zones (mm) against F. solani. (c) Inhibition zones (mm) against T. rubrum.
| (a) |
| | Complexes | Concentrations (μgmL−1) | | 5 | 10 | 20 | 40 |
| | SPFX | 7.21 ± 0.2 | 15.3 ± 0.21 | 16.31 ± 0.04 | 17.28 ± 0.11 | | S12 | 8.09 ± 0.36** (−12.21) | 9.29 ± 0.1** (39.28) | 11.1 ± 0.08** (31.94) | 14.05 ± 0.25** (18.69) | | S13 | 8.84 ± 0.16** (−22.61) | 11.01 ± 0.27** (28.04) | 15.08 ± 0.18** (7.54) | 18.32 ± 0.14** (−6.02) | | S14 | 0 ± 0** (100) | 0 ± 0** (100) | 9.31 ± 0.25** (42.92) | 10.28 ± 0.23** (40.51) | | S15 | 6.97 ± 0.07** (3.33) | 10.16 ± 0.2** (33.59) | 12.21 ± 0.12** (25.14) | 14.37 ± 0.06** (16.84) | ANOVA
(df = 10, 22) | F-270.407 | F-26.145 | F-78.461 | F-52.516 |
|
|
Mean ± S.D (percent zone of inhibition), **, *.
|
| (b) |
| | Complexes | Concentrations (μgmL−1) | | 5 | 10 | 20 | 40 |
| | SPFX | 0 ± 0 | 0 ± 0 | 10.2 ± 0.04 | 11.12 ± 0.07 | | S12 | 20.23 ± 0.24** (0) | 22.2 ± 0.22** (0) | 23.29 ± 0.06** (−128.33) | 27.06 ± 0.2** (−143.35) | | S13 | 22.06 ± 0.06** (0) | 24.06 ± 0.15** (0) | 28.22 ± 0.09** (−176.67) | 30.04 ± 0.02** (−170.14) | | S14 | 12.09 ± 0.22** (0) | 15.98 ± 0.04** (0) | 21.17 ± 0.35** (−107.55) | 24.24 ± 0.06** (−117.99) | | S15 | 17.26 ± 0.14** (0) | 22.03 ± 0.27** (0) | 26.08 ± 0.16** (−155.69) | 30.13 ± 0.2** (−170.95) | ANOVA
(df = 10, 22) | F-67.16 | F-124.599 | F-246.703 | F-133.773 |
|
|
Mean ± S.D (percent zone of inhibition), **, *.
|
| (c) |
| | Complexes | Concentrations (μgmL−1) | | 5 | 10 | 20 | 40 |
| | SPFX | 0 ± 0 | 20.4 ± 0.07 | 23.07 ± 0.05 | 24.29 ± 0.13 | | S12 | 22.22 ± 0.14** (0) | 22.07 ± 0.4** (−8.19) | 24.24 ± 0.15** (−5.07) | 27.06 ± 0.09** (−11.4) | | S13 | 18.95 ± 0.37** (0) | 25.31 ± 0.07** (−24.07) | 26.27 ± 0.27** (−13.87) | 27.08 ± 0.31** (−11.49) | | S14 | 12.22 ± 0.09** (0) | 17.02 ± 0.17** (16.57) | 19.11 ± 0.08** (17.17) | 22.18 ± 0.07** (8.69) | | S15 | 18.24 ± 0.1** (0) | 21.32 ± 0.17** (−4.51) | 24.1 ± 0.03** (−4.46) | 27.25 ± 0.19** (−12.19) | ANOVA
(df = 10, 22) | F-252.324 | F-2663.194 | F-476.634 | F-315.709 |
|
|
Mean ± S.D (percent zone of inhibition), **, *.
|
