About this Journal Submit a Manuscript Table of Contents
Journal of Chemistry
Volume 2013 (2013), Article ID 309179, 8 pages
http://dx.doi.org/10.1155/2013/309179
Research Article

Synthesis, Characterization, and Physicochemical Studies of Mixed Ligand Complexes of Inner Transition Metals with Lansoprazole and Cytosine

Chemical Laboratory, Government Motilal Vigyan Mahavidhalaya, Bhopal, India

Received 29 January 2012; Revised 11 July 2012; Accepted 13 July 2012

Academic Editor: Artur Silva

Copyright © 2013 Sarika Verma et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Few complexes of inner transition metals [Th(IV), Ce(IV), Nd(III), Gd(III)] have been synthesized by reacting their metal salts with lansoprazole, 2-([3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methylsulfinyl)-1H-benzoimidazole and cytosine. All the complexes were synthesized in ethanolic medium. The yield percentage rangs from 80 to 90%. The complexes are coloured solids. The complexes were characterized through elemental analyses, conductance measurements, and spectroscopic methods (FT IR, FAB Mass, 1H NMR and UV). An IR spectrum indicates that the ligand behaves as bidentate ligands. The metal complexes have been screened for their antifungal activity towards Aspergillus niger fungi. The interaction of inner transition metals with lansoprazole, in presence of cytosine, has also been investigated potentiometrically at two different temperatures °C and °C and at 0.1 M (KNO3) ionic strength. The stability constants of ternary complexes indicate the stability order as Th(IV) < Ce(IV) < Gd(III) < Nd(III). values obtained are positive and suggest greater stabilization of ternary complexes. The values of thermodynamic parameters (free energy ( ), enthalpy ( ), and entropy ( ) are also calculated.