Development and Validation of a Specific Stability Indicating High Performance Liquid Chromatographic Methods for Related Compounds and Assay of Solifenacin Succinate

Table 6

Summary of robustness results.

S. No.	Parameter	Variation	Resolution between solifenacin and impurity-C	Resolution between impurity-A and B
1	Temperature (±5°C of set temperature)	(a) At 33°C	3.8	8.7
		(b) At 37°C	3.4	8.1
2	Flow rate (±20% of the set Flow)	(a) At 0.8 mL/min	3.9	8.9
		(b) At 1.2 mL/min	3.5	8.3
3	pH (±0.2 units of set pH)	(a) At 3.3	3.1	8.8
		(b) At 3.7	3.3	8.6