Synthesis and Evaluation of Novel Fluorinated 2-Styrylchromones as Antibacterial Agents

Table 3

Activity indices of 200 µg/mL 2-styrylchromone derivatives in comparison to tetracycline.

Comp.	Conc.; mM	B. subtilis; ATCC 6633	E. faecium; ATCC 51299	S. aureus; ATCC 29212	S. aureus; ATCC 43300	S. sciuri; ATCC 29062	S. xylosus; ATCC 35033	E. coli; ATCC 25922	E. coli; ATCC 35218	K. pneumoniae; ATCC 700603	P. aeruginosa; ATCC 35032
5-a	0.75	0.56±0.02	0	0.50±0.00	0.31±0.02	0	0	0.52±0.02	0	0	0
5-b	0.75	0.61±0.01	0	0.54±0.01	0.50±0.00	0	0	0.44±0.01	0	0	0
5-c	0.75	0.67±0.01	0	0.29±0.01	0.02±0.01	0	0	0.44±0.01	0	0	0
5-d	0.70	0.69±0.01	0	0.68±0.01	0.41±0.01	0	0	0.42±0.00	0.44±0.01	0	0
5-e	0.70	0.75±0.01	0	0	0	0.48±0.01	0	0.44±0.01	0.61±0.01	0	0
5-f	0.75	0.50±0.01	0	0	0	0	0	0	0	0	0
5-g	0.75	0.56±0.01	0.46±0.01	0.43±0.00	0.34±0.01	0.32±0.01	0.27±0.01	0	0	0	0
5-h	0.72	0.58±0.01	0	0	0	0	0	0	0	0	0
5-i	0.65	0.64±0.00	0	0.32±0.01	0	0	0	0	0	0	0
5-j	0.68	0	0	0	0	0	0	0	0	0	0
*TE30	0.45	36±0.12	22±0.00	28±0.00	32±0.12	25±0.06	36±0.00	27±0.17	23±0.17	12±0.06	14±0.17

∗TE30: tetracycline inhibition zone (mm).