Validation of Quetiapine Fumarate in Pharmaceutical Dosage by Reverse-Phase HPLC with Internal Standard Method

<table class="table-group" id="tab10"><tr><td><table class="table"><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr class="thead"><td align="left">Marketed formulation</td><td align="center">Drug</td><td align="center">% amount obtained</td><td align="center">% RSD</td></tr><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr><td align="left">Brand 1</td><td align="center">Quetiapine-200 mg</td><td align="center"><span style="width: 82.525002px;"><svg height="11.4" id="M22" style="vertical-align:-0.3003pt" version="1.1" viewbox="0 0 82.525002 11.4" width="82.525002" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg></span></td><td align="center">0.36</td></tr><tr><td align="left">Brand 2</td><td align="center">Quetiapine-300 mg</td><td align="center"><span style="width: 82.525002px;"><svg height="11.2875" id="M23" style="vertical-align:-0.3003pt" version="1.1" viewbox="0 0 82.525002 11.2875" width="82.525002" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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t98.5 -62.5q61 48 61 124q0 59 -29.5 90t-69.5 31zM248 20q46 0 76.5 33.5t30.5 89.5q0 50 -39 85.5t-110 71.5q-81 -54 -81 -137q0 -67 35.5 -105t87.5 -38z" id="x38"></path></g><g transform="matrix(.017,-0,0,-.017,16.381,10.862)"><path d="M113 -12q-24 0 -39.5 16t-15.5 42q0 24 16 40.5t40 16.5t40 -16.5t16 -40.5q0 -26 -16 -42t-41 -16z" id="x2E"></path></g><g transform="matrix(.017,-0,0,-.017,20.257,10.862)"><path d="M153 550l-26 -186q79 31 111 31q90 0 141.5 -51t51.5 -119q0 -93 -89 -166q-85 -69 -173 -71q-32 0 -61.5 11.5t-41.5 23.5q-18 17 -17 34q2 16 22 33q14 9 26 -1q61 -50 124 -50q60 0 93 43.5t33 104.5q0 69 -41.5 110t-121.5 41q-53 0 -102 -20l38 305h286l6 -8
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</svg></span></td><td align="center">0.35</td></tr><tr class="table-tr"><td colspan="4"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td>Each value is a result of triplicate analysis.<br/></td></tr></table>

Results of quetiapine fumarate in marketed product.

Journal of Chemistry

tab10

Table 10

Table 10: Validation of Quetiapine Fumarate in Pharmaceutical Dosage by Reverse-Phase HPLC with Internal Standard Method 