Validation of Quetiapine Fumarate in Pharmaceutical Dosage by Reverse-Phase HPLC with Internal Standard Method

Table 8

Specificity data for stress conditions.

Stress condition	Retention time	Area	Purity 1 angle	Purity 1 threshold	USP plate count	USP tailing
Untreated	3.95	757150	0.07	0.26	5560	1.22
Oxidation	3.85	744086	0.20	0.24	4499	1.40
Thermal	3.93	747898	0.15	0.28	4300	1.42
Alkaline	3.78	750779	0.22	0.24	4200	1.38
Acidic	3.94	754257	0.14	0.25	4800	1.35
UV	3.93	745145	0.19	0.24	4856	1.26