Stress Degradation Assessment of Lamotrigine Using a Validated Stability-Indicating HPTLC Method

Table 3

Statistical evaluation of the results obtained by the proposed and reference methods for the determination of LAM in tablets.

Pharmaceutical preparation	Proposed method						Reference method^d
	Mean ± SD^a	RSD%	𝑆^2b	Mean ± SD^a	RSD%	𝑆^2b	𝑡^c	𝐹^c
Lamictal 100 tablets	100.08 ± 0.82	0.82	0.67	99.62 ± 0.74	0.74	0.55	0.94	1.22
Lamictal 50 tablets	99.58 ± 0.69	0.70	0.47	100.14 ± 0.50	0.50	0.25	1.47	1.88
Lamictal 25 tablets	99.68 ± 0.62	0.62	0.38	99.85 ± 0.83	0.83	0.69	1.89	1.82
Lamotrigine 100 tablets	99.80 ± 0.58	0.58	0.34	99.85 ± 0.46	0.46	0.21	0.13	1.62
Lamotrigine 50 tablets	99.91 ± 0.74	0.74	0.55	100.01 ± 1.15	1.15	1.32	0.17	2.40
Lamotrigine 25 tablets	99.63 ± 0.76	0.76	0.58	99.41 ± 0.96	0.97	0.93	0.39	1.60
Laptorgine 200 tablets	99.77 ± 0.58	0.58	0.34	99.39 ± 1.04	1.05	1.08	0.73	3.20
Laptorgine 25 tablets	99.62 ± 0.82	0.82	0.67	99.45 ± 0.80	0.80	0.64	0.36	1.05
Larogen 100 tablets	99.52 ± 1.38	1.39	1.90	99.76 ± 0.85	0.85	0.73	0.34	2.60

aMean %R ± SD of 5 experiments.
^bVariance (𝑆²).
^cThe theoretical 𝑡 and 𝐹 values, 2.31 and 6.39, respectively at 𝑃=0.05.
^d[9].