Research Article
Stress Degradation Assessment of Lamotrigine Using a Validated Stability-Indicating HPTLC Method
Table 4
% Recoveries of LAM and
values of detected peaks under different stress conditions.
| | Condition | (%) Recovery | value of
detected peaks |
| Acid hydrolysis
(5 N, 80°C, 2 h) | 85.25 | 0.01, 0.02, 0.06, 0.1 | Base hydrolysis
(2.5 N, 80°C, 2 h) | 77.84 | 0.01, 0.1 | Neutral hydrolysis
(80°C, 72 h) | 95.91 | — | Hydrogen peroxide
(30%, 80°C, 4 h) | 87.20 | 0.03, 0.5 | Dry heat
(100°C, 72 h) | 99.22 | — | Humidity
(75% RH, 40°C, 72 h) | 99.14 | — | Daylight
(72 h) | 99.92 | — |
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