Research Article
Synthesis and Analgesic Activity of Novel Derivatives of 1,2-Substituted Benzimidazoles
Table 1
Physicochemical data for synthesized compounds.
| Compound code | Molecular formula | Molecular weight | Yield (%) | Melting point (°C) | Rf value | Solubility in DMSO |
| 1a | C20H27N5 | 337.46188 | 92.0 | 120–122 | 0.44 | soluble | 1b | C20H26N6 | 350.46064 | 73.0 | 183–185 | 0.19 | soluble | 1c | C21H27N5 | 349.47258 | 23.0 | 218–220 | 0.29 | soluble | 1d | C20H25N5O | 351.4454 | 43.0 | 118–120 | 0.24 | soluble | 1e | C18H23N5 | 309.40872 | 37.50 | 230–232 | 0.31 | soluble | 2 | C18H20N4O | 308.3776 | 22.0 | 238–240 | 0.39 | soluble |
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* Eluants for TLC were ethyl acetate: benzene (1: 4).
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