Synthesis and Analgesic Activity of Novel Derivatives of 1,2-Substituted Benzimidazoles

Table 1

Physicochemical data for synthesized compounds.

Compound code	Molecular formula	Molecular weight	Yield (%)	Melting point (^°C)	Rf value	Solubility in DMSO
1a	C20H27N5	337.46188	92.0	120–122	0.44	soluble
1b	C20H26N6	350.46064	73.0	183–185	0.19	soluble
1c	C21H27N5	349.47258	23.0	218–220	0.29	soluble
1d	C20H25N5O	351.4454	43.0	118–120	0.24	soluble
1e	C18H23N5	309.40872	37.50	230–232	0.31	soluble
2	C18H20N4O	308.3776	22.0	238–240	0.39	soluble

^* Eluants for TLC were ethyl acetate: benzene (1: 4).