Synthesis and Analgesic Activity of Novel Derivatives of 1,2-Substituted Benzimidazoles

Table 2

Acetic-acid-induced writhing response in mice.

S. no.	Derivative	Dosage	No. of writhings in 20 min (mean ± S.E.M)	% Analgesic activity^*
1	Control	Vehicle	75.66±2.15	0
2	1a	20 mg/kg	19.00±1.84	74.88^**
3	1b	20 mg/kg	33.66±1.83	55.51^**
4	1c	20 mg/kg	33.33±1.27	55.94^**
5	1d	20 mg/kg	26.83±1.41	64.53^**
6	1e	20 mg/kg	23.33±2.00	69.16^**
7	2	20 mg/kg	22.83±1.42	70.12^**
8	Diclofenac	20 mg/kg	08.16±0.85	89.21^***

𝑁=6; Student’s t-test;
^*𝑃≤0.05;
^**𝑃≤0.01;
^***𝑃≤0.0001 when compared with control.