Nimesulide Based Novel Glycolamide Esters: Their Design, Synthesis, and Pharmacological Evaluation

Table 1

Synthesis of nimesulide based glycomide esters 4.^a

Entry	RCOOH (3); R =	Products (4)	Time; (min)	% yield^b
(1)			30	91
(2)			30	95
(3)			20	80
(4)			30	90
(5)			30	70
(6)			15	75
(7)			10	98
(8)			30	78
(9)			45	80
(10)			15	92
(11)			30	90
(12)			15	90

aAll the reactions were performed using chlorocompound 2 (0.01 mmol) and acid 3 (0.01 mol) in the presence of NaI (0.001 mol), Et₃N (0.011 mmol), and DMF (15 mL) at 90°C.
bIsolated yield.