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Journal of Chemistry
Volume 2013 (2013), Article ID 818739, 7 pages
http://dx.doi.org/10.1155/2013/818739
Research Article

Synthesis, Antibacterial, and Antifungal Activities of Novel Pyridazino Carbazoles

1Department of Environmental Sciences, Kinnaird College for Women, Lahore 54000, Pakistan
2Department of Microbiology, University of Health Sciences, Lahore 54000, Pakistan
3Department of Chemistry, Lahore College for Women University, Lahore 54000, Pakistan
4Department of Chemistry (Girls), College of Science, King Faisal University, Al-Ahsa 31982, Saudi Arabia

Received 30 September 2012; Revised 25 November 2012; Accepted 25 November 2012

Academic Editor: Naoki Toyooka

Copyright © 2013 Ghazala Yaqub et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Strategy to synthesize novel carbazole, that is, 2,3-dihydro-2-phenyl-6H-pyridazino[4, 5-b]carbazole-1,4-dione (2), is developed as key reaction. This novel compound showed ideal reactivity toward different functional groups like methyl, carboxylic, nitro, piperazine, and amine; thus series of its derivatives are synthesized sequentially with the aim to fuel up the carbazole compounds with new versatile derivatives. All compounds were investigated for their activity against bacteria (MRSA and S. typhi) and fungi (Candida albicans). Among tested compounds 3, 6, and 8 exhibited pronounced antibacterial activities while 2, 5, and 9 also showed moderate activities. 2, 3, 5, 7, and 9 showed stronger antifungal activity against Candida albicans comparable to positive control.