Synthesis of New Fluorine Substituted Heterocyclic Nitrogen Systems Derived from p-Aminosalicylic Acid as Antimycobacterial Agents

Table 1

Results of the primary antituberculosis screening of compounds 1–17.

Compound	MIC (μg/mL)^a	GI (%)^b
1	<6.25	95
2	<6.25	96
3	<6.25	98
4	<6.25	98
5	<6.25	98
7	<6.25	94
9	<6.25	94
10	<6.25	98
11	<6.25	92
12	<6.25	92
13	<6.25	98
14	<6.25	95
16	<6.25	96
17	<6.25	100

aMIC (minimum inhibitory concentration) of Rifampicin: 0.125–0.25 μg/mL versus M. tuberculosis H37Rv.
bGrowth inhibition of virulent H37Rv strains of M. tuberculosis.