Synthesis of New Fluorine Substituted Heterocyclic Nitrogen Systems Derived from p-Aminosalicylic Acid as Antimycobacterial Agents

Table 2

Results of second level antituberculosis assay.

Compound	MIC (μg/mL)^a	IC50 (μg/mL)^a	SI; (IC50/MIC)	log𝑃^b
3	6.25	29	4.64	2.82
4	6.25	27	4.32	2.17
5	4.25	14	3.29	4.2
10	6.25	27	4.32	1.93
13	3.78	12	3.17	3.37
17	6.25	30	4.80	2.12

aActual minimum inhibitory concentration (MABA assay).
bCalculated log𝑃.