Development and Validation of HLPC Method for the Estimation of Lamotrigine in Bulk and Pharmaceutical Formulations

<table class="table-group" id="tab3"><tr><td><table class="table"><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr class="thead"><td align="left">S. no.</td><td align="center">Concentration <svg height="9.6750002" id="M2" style="vertical-align:-2.29482pt" version="1.1" viewbox="0 0 9.6374998 9.6750002" width="9.6374998" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,9.675)">
<g transform="translate(72,-64.26)">
<text transform="matrix(1,0,0,-1,-71.95,66.6)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝜇</tspan>
</text>
</g>
</g>
</svg>g/mL</td><td align="center">Area of the peak</td></tr><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr><td align="left">1</td><td align="center">5</td><td align="center">1025925</td></tr><tr><td align="left">2</td><td align="center">10</td><td align="center">2027807</td></tr><tr><td align="left">3</td><td align="center">15</td><td align="center">3095827</td></tr><tr><td align="left">4</td><td align="center">20</td><td align="center">4058008</td></tr><tr><td align="left">5</td><td align="center">25</td><td align="center">5068723</td></tr><tr><td align="left" colspan="3"><hr/></td></tr><tr><td align="center" colspan="2">Slope</td><td align="center">16351</td></tr><tr><td align="center" colspan="2">Intercept</td><td align="center">78025</td></tr><tr><td align="center" colspan="2">Correlation coefficient</td><td align="center">0.9998</td></tr><tr class="table-tr"><td colspan="3"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td>Acceptance criteria: correlation coefficient should be not less than 0.999.<br/></td></tr></table>

Linearity of the drug concentration with peak area.

Journal of Chemistry

tab3

Table 3

Table 3: Development and Validation of HLPC Method for the Estimation of Lamotrigine in Bulk and Pharmaceutical Formulations 