Quantitative Structure Activity Relationship Studies of Topoisomerase I Inhibitors as Potent Antibreast Cancer Agents

Table 4

Statistical validation parameters obtained in the MLR, PLS, and FFNN analyses.

Statistical parameter	MLR		PLS		FFNN
	Training set	Test set	Training set	Test set	Training set	Test set
𝑟^2	0.932	0.739	0.932	0.800	0.931	0.829
𝑟^2cv	0.897	—	0.913	—	0.931	—
𝑟^2ext	—	0.747	—	0.752	—	0.793
𝑟^2−𝑟^2𝑜/𝑟^2	0.001	0.193	0.002	0.176	0.002	0.107
𝑟^2−𝑟𝑜^′2/𝑟^2	0	0.072	0	0.067	0	0.045
𝑘	0.954	0.946	0.953	0.965	0.963	1.001
𝑘^′	1	0.808	1	0.802	0.989	0.814