HMG-CoA Reductase Inhibitors from Monascus-Fermented Rice

Table 1

¹H NMR (600 MHz) data for 1, 2, and monacolin L (𝛿 in ppm, 𝐽 in Hz).

No.	1 ^a	2 ^a	Monacolin L^b
1	2.58 (m)	—	1.40 (m)
2	2.72 (m)	—	2.31 (m)
3	5.74 (dd, 9.6, 3.0)	7.27 (d, 8.4)	5.72 (m)
4	6.35 (dd, 9.6, 2.4)	7.56 (d, 8.4)	5.87 (m)
4a	—	—	—
5	6.86 (brs)	7.58 (brs)	5.39 (m)
6	—	—	2.32 (m)
7	6.93 (d, 7.8)	7.34 (dd, 9.0, 1.2)	1.46 (m), 1.53 (m)
8	6.96 (d, 7.8)	7.94 (d, 9.0)	1.20 (m), 1.81 (m)
8a	—	—	2.05 (m)
1′	—	—	—
2′	2.55 (m)	2.68 (ddd, 17.4, 3.6, 1.8)	2.44 (dd, 15.0, 8.4)
	2.66 (dd, 18.0, 5.4)	2.77 (dd, 17.4, 4.8)	2.55 (dd, 15.0, 4.8)
3′	4.28 (m)	4.40 (m)	4.20 (m)
4′	1.63 (m), 1.86 (m)	1.82 (m), 2.00 (m)	1.62 (m), 1.78 (m)
5′	4.56 (m)	4.86 (m)	3.76 (m)
6′	1.42 (m), 1.66 (m)	1.92 (m), 1.98 (m)	1.60 (m), 1.65 (m)
7′	1.58 (m), 1.76 (m)	3.16 (m), 3.37 (m)	1.30 (m), 1.73 (m)
2-Me	1.06 (d, 7.8)	2.49 (brs)	0.99 (dd, 7.2, 1.8)
6-Me	2.29 (s)	2.50 (brs)	0.90 (dd, 7.2, 3.0)

aCDCl₃.
bCD₃OD.