Research Article
Synthesis of Substituted Thieno[2,3-d]pyrimidin-4-ones and Their Testing for Evaluation of Cytotoxic Activity on Mammalian Cell Models
Table 2
IC50 determination of substances 5–16 on HeLa and P3X cells after 24-hour culturing (MTT assay).
| | Sample | P3X | Hela |
| | 5 | 86,4 μg/mL | >500 μg/mL | | 6 | 195 μg/mL | >500 μg/mL | | 7 | 249,7 μg/mL | >500 μg/mL | | 8 | >500 μg/mL | >500 μg/mL | | 9 | >500 μg/mL | >500 μg/mL | | 10 | 93,1 μg/mL | >500 μg/mL | | 11 | 90,0 μg/mL | >500 μg/mL | | 12 | 103,8 μg/mL | >500 μg/mL | | 13 | >500 μg/mL | >500 μg/mL | | 14 | >500 μg/mL | >500 μg/mL | | 15 | >500 μg/mL | >500 μg/mL | | 16 | >500 μg/mL | >500 μg/mL |
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