Synthesis of 1,8-Naphthyridine Derivatives under Ultrasound Irradiation and Cytotoxic Activity against HepG2 Cell Lines

<table class="table-group" id="tab3"><tr><td><table class="table"><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr class="thead"><td align="left">Compounds</td><td align="center"><svg height="15.65" id="M6" style="vertical-align:-3.39066pt" version="1.1" viewbox="0 0 30.3125 15.65" width="30.3125" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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<g transform="matrix(.012,-0,0,-.012,18.2,15.45)"><path d="M153 550l-26 -186q79 31 111 31q90 0 141.5 -51t51.5 -119q0 -93 -89 -166q-85 -69 -173 -71q-32 0 -61.5 11.5t-41.5 23.5q-18 17 -17 34q2 16 22 33q14 9 26 -1q61 -50 124 -50q60 0 93 43.5t33 104.5q0 69 -41.5 110t-121.5 41q-53 0 -102 -20l38 305h286l6 -8
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</svg>M)</td></tr><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr><td align="left">DOX</td><td align="center">0.04</td></tr><tr><td align="left"><b>3a</b></td><td align="center">0.071</td></tr><tr><td align="left"><b>3b</b></td><td align="center">0.064</td></tr><tr><td align="left"><b>5</b></td><td align="center">0.091</td></tr><tr><td align="left"><b>6</b></td><td align="center">0.067</td></tr><tr><td align="left"><b>8</b></td><td align="center">0.063</td></tr><tr><td align="left"><b>9a</b></td><td align="center">0.058</td></tr><tr><td align="left"><b>9b</b></td><td align="center">0.048</td></tr><tr><td align="left"><b>9c</b></td><td align="center">0.067</td></tr><tr class="table-tr"><td colspan="2"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Journal of Chemistry

tab3

Table 3

Table 3: Synthesis of 1,8-Naphthyridine Derivatives under Ultrasound Irradiation and Cytotoxic Activity against HepG2 Cell Lines 