Synthesis and Docking Studies of the Novel N-(2,2-Di(1H-pyrrol-2-yl)ethyl)adamantane-1-carboxamide, a Potential 11β-HSD1 Inhibitor
Figure 3
(a) Compound 1 docked in the active site. (b) Comparison of compound 1 and 2-(2-chloro-4-fluorophenoxy)-2-methyl-N-[(1R,2S,3S,5S,7S)-5-(methylsulfonyl)-2-adamantyl]propanamide after docking. (c) Hydrogen bonding interactions between compound 1 and the amino acid residues Ser 170 an TYR 183. (d) Binding pocket of compound 1.
