Pharmacological Profile of Quinoxalinone

Table 11

Enzyme inhibition activity of compound 79 against the Cdk family and other kinases.

Kinases	IC50 (nM)	Selectivity (fold)
Cdk4	4.1	1.0
Cdk6	12
Cdk2	3.4
Cdk1	1.0
Cdk5	4.5
Cdk7	660
PKA		>730
PKC		230
ERK1		>730
ERK2		>730
P38𝛼		>2400
KDR		250
Flt-1		330
Flt-4		71
FGFR1		2000
FGFR2		610
Src		260
Tle-2		>4900
PDGF𝛽		480
EGFR		>2400