Review Article
Pharmacological Profile of Quinoxalinone
Table 3
Antifungal activities of compounds 9a–l.
| | | | MIC (g/mL) | | R1 | R2 | Mold | Yeast | | | | A. n.a | P. c.b | C. c.c | A. p.d | A. s.e | M. s.f | G. v.g | R. r.h | S. c.i |
| 9a | CH3 | CH3 | >100 | >100 | >100 | >100 | >100 | >100 | >100 | >100 | >100 | 9b | CN | H | 50 | 25 | 25 | 50 | 25 | 25 | >100 | 100 | 50 | 9c | F | H | 50 | 50 | 50 | 100 | 50 | 25 | 100 | 100 | 50 | 9d | Cl | H | 50 | 100 | 25 | >100 | >100 | 50 | >100 | >100 | >100 | 9e | Br | H | 100 | 100 | 50 | >100 | >100 | 50 | >100 | >100 | >100 | 9f | OCH3 | H | 50 | >100 | 50 | 100 | 100 | 50 | >100 | >100 | 100 | 9g | CF3 | H | 50 | 50 | 100 | 50 | 100 | 25 | >100 | 100 | 50 | 9h | NO2 | H | 100 | 100 | 50 | 100 | 25 | 50 | 100 | >100 | 50 | 9i | COOH | H | >100 | >100 | >100 | >100 | >100 | >100 | >100 | >100 | >100 | 9j | CO2CH3 | H | 50 | 100 | 100 | 50 | 100 | 25 | >100 | >100 | 50 | 9k | CO2CH2CH3 | H | >100 | >100 | >100 | 100 | >100 | 100 | >100 | 100 | 100 | 9l | OH | H | >100 | >100 | >100 | >100 | >100 | >100 | >100 | >100 | >100 |
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Aspergillus niger, bPenicillium citrinum, cCladosporium cladosporioides, dAureobasidium pullulans, eAlternaria sp., fMucor spinescens, gGliocladium virens, hRhodotorula rubra, iSaccharomyces cerevisiae.
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