Research Article
Synthesis and Biological Evaluation of New Substituted 3-[4-(Phenylsulfonamido)benzoyl]-2H-1-benzopyran-2-one Derivatives as α-Glucosidase Inhibitors
Table 1
The
α-glucosidase inhibitory activity of new substituted 3-
4-(phenylsulfonamido)benzoyl
-2
H-1-benzopyran-2-one derivatives.
| Number | | | | IC50 (M)a |
| 10 | H | H | F | 7.568 ± 0.575 | 11 | H | OH | F | 0.282 ± 0.038 | 12 | H | N(C2H5)2 | F | 0.085 ± 0.014 | 13 | OCH3 | OH | F | 0.075 ± 0.012 | 14 | H | H | Cl | 1.088 ± 0.232 | 15 | H | OH | Cl | 0.171 ± 0.034 | 16 | H | N(C2H5)2 | Cl | 0.108 ± 0.019 | 17 | OCH3 | OH | Cl | 0.025 ± 0.005 | 18 | H | H | Br | 0.014 ± 0.003 | 19 | H | OH | Br | 0.199 ± 0.016 | 20 | H | N(C2H5)2 | Br | 0.125 ± 0.035 | 21 | OCH3 | OH | Br | 0.036 ± 0.008 | 22 | H | H | OCH3 | 0.073 ± 0.012 | 23 | H | OH | OCH3 | 0.018 ± 0.003 | 24 | H | N(C2H5)2 | OCH3 | 0.037 ± 0.006 | 25 | OCH3 | OH | OCH3 | 0.069 ± 0.011 | 26 | H | N(C2H5)2 | C(CH3)3 | —b | Acarbose | | | | 29.26 ± 3.23 |
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IC50 values are represented as means ± SD ( = 2-3). bLess than 50% inhibition at 10 g/mL.
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