Synthesis and Biological Evaluation of New Substituted 3-[4-(Phenylsulfonamido)benzoyl]-2H-1-benzopyran-2-one Derivatives as α-Glucosidase Inhibitors

Table 1

The α-glucosidase inhibitory activity of new substituted 3-[4-(phenylsulfonamido)benzoyl]-2H-1-benzopyran-2-one derivatives.

Number	R1	R2	R3	IC50 (𝜇M)^a
10	H	H	F	7.568 ± 0.575
11	H	OH	F	0.282 ± 0.038
12	H	N(C2H5)2	F	0.085 ± 0.014
13	OCH3	OH	F	0.075 ± 0.012
14	H	H	Cl	1.088 ± 0.232
15	H	OH	Cl	0.171 ± 0.034
16	H	N(C2H5)2	Cl	0.108 ± 0.019
17	OCH3	OH	Cl	0.025 ± 0.005
18	H	H	Br	0.014 ± 0.003
19	H	OH	Br	0.199 ± 0.016
20	H	N(C2H5)2	Br	0.125 ± 0.035
21	OCH3	OH	Br	0.036 ± 0.008
22	H	H	OCH3	0.073 ± 0.012
23	H	OH	OCH3	0.018 ± 0.003
24	H	N(C2H5)2	OCH3	0.037 ± 0.006
25	OCH3	OH	OCH3	0.069 ± 0.011
26	H	N(C2H5)2	C(CH3)3	—^b
Acarbose				29.26 ± 3.23

aIC₅₀ values are represented as means ± SD (𝑛 = 2-3). ^bLess than 50% inhibition at 10 𝜇g/mL.