Synthesis and Biological Activities of Some Novel (E)-Alpha-(methoxyimino)benzeneacetate Derivatives with Modified 1,2,4-Triazole Moiety

<table>Synthetic route of target compounds 6a–6n. <svg height="8.9689pt" id="M85" style="vertical-align:-0.1625795pt" version="1.1" viewbox="0 -8.80632 40.6412 8.9689" width="40.6412pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0135,0,0,-0.0135,0,0)"><path d="M660 23C638 31 621 43 599 66C580 87 558 119 523 175C493 221 456 287 441 317C508 344 566 392 566 480C566 542 539 586 499 613C458 640 408 650 320 650H39V615C112 608 121 598 121 518V134C121 51 110 42 35 35V0H337V35C261 42 252 51 252 134V280H271C303 280 321 267 337 237C366 184 393 130 419 89C460 26 498 -2 624 -8C637 -8 648 -9 654 -9L660 23ZM252 320V563C252 584 254 594 261 600C267 606 281 610 306 610C362 610 424 572 424 465C424 414 410 374 376 346C354 327 320 320 278 320H252Z" id="g13-80"></path><glyph.data ascent="1024" descent="-360" horiz-adv-x="659" vert-adv-y="659"></glyph.data></g><g transform="matrix(.0135,0,0,-0.0135,12.727,0)"><path d="M535 323V373H52V323H535ZM535 138V188H52V138H535Z" id="g117-34"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="587" vert-adv-y="587"></glyph.data></g><g transform="matrix(.0135,0,0,-0.0135,20.68,0)"><path d="M116 412C83 412 59 388 59 355C59 321 83 297 115 297S170 321 170 355C170 388 147 412 116 412ZM114 -12C147 -12 171 11 171 46C171 78 147 103 115 103C84 103 60 78 60 46C60 11 84 -12 114 -12Z" id="g113-59"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="228" vert-adv-y="228"></glyph.data></g><g transform="matrix(.0135,0,0,-0.0135,27.554,0)"><path d="M179 359C209 485 294 542 343 567C378 584 421 597 450 603L443 641C405 636 339 624 294 609C178 570 28 456 28 243C28 84 127 -12 253 -12C385 -12 480 89 480 215C480 328 403 402 288 402C272 402 254 394 229 382L179 359ZM234 331C302 331 349 265 349 171C349 106 335 29 273 29C220 29 166 106 166 239C166 263 168 303 172 320C192 327 211 331 234 331Z" id="g13-52"></path><glyph.data ascent="1024" descent="-360" horiz-adv-x="500" vert-adv-y="500"></glyph.data></g><g transform="matrix(.0135,0,0,-0.0135,34.328,0)"><path d="M465 45L455 77C444 72 433 69 421 69C404 69 389 81 389 128V293C389 349 380 392 337 425C310 445 280 454 239 454C182 443 111 409 73 383C51 366 38 353 38 335C38 309 74 285 101 285C121 285 136 293 143 319C151 350 160 374 171 388C180 400 191 406 205 406C241 406 265 371 265 308V278C242 258 165 234 106 212C54 192 30 168 30 116C30 54 81 -12 165 -12C185 -12 232 21 270 46C274 34 281 21 295 9C308 -3 329 -12 356 -12L465 45ZM265 79C249 67 238 63 223 63C200 63 163 84 163 139C163 174 179 192 210 208C231 219 247 229 265 239V79Z" id="g13-95"></path><glyph.data ascent="1024" descent="-360" horiz-adv-x="466" vert-adv-y="466"></glyph.data></g></svg>. C6H5; 6b. 4-CH3C6H4; 6c. 4-N(CH3)2C6H4; 6d. 2-OHC6H4; 6e. 3-OHC6H4; 6f. 4-OHC6H4; 6g. 2-NO2C6H4; 6h. 3-NO2C6H4; 6i. 4-NO2C6H4; 6j. 2-ClC6H4; 6k. 3-ClC6H4; 6l. 4-ClC6H4; 6m. 2, 4-Cl2C6H3; 6n. 3,4-Cl2C6H3.</table>

Journal of Chemistry

sch1

Scheme 1

Scheme 1: Synthesis and Biological Activities of Some Novel (E)-Alpha-(methoxyimino)benzeneacetate Derivatives with Modified 1,2,4-Triazole Moiety