Research Article
Green Route for Efficient Synthesis of Novel Amino Acid Schiff Bases as Potent Antibacterial and Antifungal Agents and Evaluation of Cytotoxic Effects
Table 3
Minimum inhibitory concentration for fungi.
| Compound | MIC (ug/mL) | Aspergillus sp. | Penicillium sp. | Alternaria brassicicola | Chaetomium orium | Lycopodium sp. | 250 | 500 | 1000 | 250 | 500 | 1000 | 250 | 500 | 1000 | 250 | 500 | 1000 | 250 | 500 | 1000 |
| 4a | + | + | + | + | + | + | + | + | + | + | + | + | + | − | − −
*
| 4b | + | + | + | + | + | + | + | + | + | + | + | + | + | + | + | 4c | + | + | − −
*
| + | + | + | + | + | + | + | + | + | + | + | + | 4d | + | + | + | + | + | + | + | + | + | + | + | + | + | + | + | 4e | + | + | + | + | + | + | + | + | + | + | + | + | + | + | + | 4f | + | + | + | + | + | + | + | + | + | + | + | + | + | + | + | 4g | + | + | − | + | + | + | + | + | + | + | + | + | − | + | + | 4h | + | + | − −
*
| + | + | + | + | + | − −
*
| + | + | − −
*
| + | + | + | 4i | + | + | + | + | + | − −
*
| + | + | − −
*
| + | + | − −
*
| + | + | + | 4j | + | + | + | + | + | + | + | + | + | + | + | + | + | + | + | 4k | + | + | + | + | + | − −
*
| + | + | − −
*
| + | + | − −
*
| + | + | − −
*
| 4l | + | + | − −
*
| + | + | + | + | + | + | + | + | − | + | + | + | 4m | + | + | − −
*
| + | + | − −
*
| + | + | − | + | + | − −
*
| + | + | − | 4n | + | + | − −
*
| + | + | + | + | + | − | + | + | − −
*
| + | + | − | 4o | + | + | + | + | + | + | + | + | − | + | + | + | + | + | − | 4p | + | + | + | + | + | + | + | + | − | + | + | − −
*
| + | + | − −
*
| Solvent DMSO | + | + | + | + | + | + | + | + | + | + | + | + | + | + | + | Itraconazole | | − − − | | − − − | − − − |
|
|
Moderately active (zone of inhibition 8–10 mm).
|