Research Article
Green Route for Efficient Synthesis of Novel Amino Acid Schiff Bases as Potent Antibacterial and Antifungal Agents and Evaluation of Cytotoxic Effects
Table 5
In vitro cytotoxic effects of amino acid Schiff bases against human colon cancer cell line Colo205.
| (a) |
| | Entry | Human colon cancer cell line Colo205 | | % control growth | | Molar drug concentration | | Experiment 1 | Experiment 2 | Experiment 3 | Average values | | 10−6 M | 10−5 M | 10−4 M | 10−3 M | 10−7 M | 10−6 M | 10−5 M | 10−4 M | 10−7 M | 10−6 M | 10−5 M | 10−4 M | 10−7 M | 10−6 M | 10−5 M | 10−4 M |
| | 4a | 98.3 | 91.4 | 91.2 | 29.4 | 96.3 | 93.2 | 91.8 | 28.9 | 90.4 | 94.9 | 83.6 | 22.9 | 95.0 | 93.2 | 88.9 | 27.0 | | 4e | 100.0 | 100.0 | 100.0 | 23.0 | 100.0 | 100.0 | 100.0 | 23.7 | 100.0 | 100.0 | 100.0 | 23.8 | 100.0 | 100.0 | 100.0 | 23.5 | | 4f | 100.0 | 98.0 | 96.3 | 39.7 | 100.0 | 96.3 | 95.1 | 38.2 | 100.0 | 100.0 | 100.0 | 43.4 | 100.0 | 98.1 | 97.1 | 40.4 | | 4h | 100.0 | 100.0 | 93.1 | −25.0 | 100.0 | 99.4 | 91.5 | −20.5 | 100.0 | 97.9 | 88.1 | −28.3 | 100.0 | 99.1 | 90.9 | −24.6 | | ADR | 73.4 | 21.7 | −64.1 | −74.7 | 71.1 | 23.3 | −70.2 | −73.5 | 67.5 | 14.1 | −66.1 | −76.3 | 70.7 | 19.7 | −66.8 | −74.8 |
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| (b) |
| | Human colon cancer cell line Colo205 | | Molar drug concentration calculated from graph | | Colo205 | LC50 | TGI | GI50 |
| | 4a | >100 | >100 | 67.2 | | 4e | >100 | >100 | 68.0 | | 4f | >100 | >100 | 85.4 | | 4h | >100 | 81.6 | 41.8 | | ADR | 67.7 | 15.3 | <10 |
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