Towards the Application of Atorvastatin to Intensify Proapoptotic Potential of Conventional Antileukemic Agents In Vitro

Figure 2

Antileukemic potential of atorvastatin (A), cladribine + mafosfamide combination (CM), or atorvastatin in combination with cladribine + mafosfamide (CM + A) in CM-resistant (R), partially resistant (P), and CM-susceptible (S) PBMC samples obtained from blood of exemplary CLL patients (numbers 1, 3, 9, 18, 19, 21, and 24). The cytotoxic potential of the tested compounds was evaluated by Permeable/Dead Cell Apoptosis Kit and their proapoptotic activity was assessed by Western blot analysis of apoptosis-related protein expression after 48 h exposure. The results were statistically significant at , , and (Wilcoxon signed rank test).