Simultaneous HPLC Determination of Chlordiazepoxide and Mebeverine HCl in the Presence of Their Degradation Products and Impurities

Table 1

Analytical performance data for determination of CDO, MBV, VER, and ACB by the proposed method.

Parameter	Result
	CDO	MBV	VER	ACB
Concentration range (µg/mL)	1.0–100.0	10.0–200.0	2.0–40.0	2.0–40.0
Limit of detection (LOD) (µg/mL)	0.23	0.67	0.05	0.15
Limit of quantification (LOQ) (µg/mL)	0.71	2.04	0.15	0.45
Correlation coefficient ()	0.9999	0.9999	0.9999	0.9999
Slope	1.05 × 10^5	2.92 × 10^4	6.93 × 10^4	6.87 × 10^4
Intercept	2.15 × 10^4	1.08 × 10^4	−1.76 × 10^4	7.34 × 10^4
Standard deviation of the residuals ()	1.50 × 10^4	9.98 × 10^3	3.81 × 10^3	8.85 × 10^3
Standard deviation of the intercept ()	7.45 × 10^3	5.95 × 10^3	1.04 × 10^3	3.12 × 10^3
Standard deviation of the slope ()	1.70 × 10^2	0.63 × 10^2	1.09 × 10^2	2.81 × 10^2
% RSD	0.91	0.99	0.94	0.94
% error (% RSD/)	0.34	0.37	0.35	0.38