Research Article
Simultaneous HPLC Determination of Chlordiazepoxide and Mebeverine HCl in the Presence of Their Degradation Products and Impurities
Table 2
Application of the proposed and comparison methods for the determination of CDO and MBV in pure form and coformulated tablets.
| Matrix | Proposed method | Comparison method [21] | CDO | MBV | CDO | MBV | Conc. taken (µg/mL) | % founda | Conc. taken (µg/mL) | % founda | % founda |
| Pure form | 1.0 | 98.00 | 10.0 | 98.17 | 101.40 | 101.53 | 2.5 | 98.60 | 20.0 | 98.25 | 98.30 | 98.16 | 5.0 | 100.00 | 40.0 | 100.10 | 100.60 | 100.66 | 15.0 | 100.06 | 60.0 | 100.10 | | | 25.0 | 99.52 | 80.0 | 100.39 | | | 50.0 | 100.55 | 100.0 | 100.46 | | | 100.0 | 99.89 | 200.0 | 99.83 | | | Mean ± SD | | 99.52 ± 0.90 | | 99.61 ± 0.98 | 100.10 ± 1.61 | 100.12 ± 1.75 | -value | | 0.753 (2.306)b | | 0.597 (2.306)b | | | -value | | 3.187 (5.14)b | | 3.176 (5.14)b | | | Coloverin A tablets (5 mg CDO + 135 mg MBV/tablet) | 3.0 | 100.22 | 81.0 | 98.25 | 101.20 | 100.88 | 5.0 | 99.98 | 135.0 | 99.01 | 98.58 | 98.95 | 7.0 | 99.05 | 189.0 | 98.58 | 100.51 | 100.38 | Mean ± SD | | 99.75 ± 0.62 | | 98.61 ± 0.38 | 100.10 ± 1.36 | 100.07 ± 1.00 | -value | | 0.402 (2.776)b | | 2.354 (2.776)b | | | -value | | 4.829 (19.00)b | | 6.91 (19.00)b | | |
|
|
Each result is the average of three separate determinations. Values between parentheses are the tabulated - and -values at [29].
|