Simultaneous HPLC Determination of Chlordiazepoxide and Mebeverine HCl in the Presence of Their Degradation Products and Impurities

Table 2

Application of the proposed and comparison methods for the determination of CDO and MBV in pure form and coformulated tablets.

Matrix	Proposed method				Comparison method [21]
	CDO		MBV		CDO	MBV
	Conc. taken (µg/mL)	% found^a	Conc. taken (µg/mL)	% found^a	% found^a
Pure form	1.0	98.00	10.0	98.17	101.40	101.53
	2.5	98.60	20.0	98.25	98.30	98.16
	5.0	100.00	40.0	100.10	100.60	100.66
	15.0	100.06	60.0	100.10
	25.0	99.52	80.0	100.39
	50.0	100.55	100.0	100.46
	100.0	99.89	200.0	99.83
Mean ± SD		99.52 ± 0.90		99.61 ± 0.98	100.10 ± 1.61	100.12 ± 1.75
-value		0.753 (2.306)^b		0.597 (2.306)^b
-value		3.187 (5.14)^b		3.176 (5.14)^b
Coloverin A tablets (5 mg CDO + 135 mg MBV/tablet)	3.0	100.22	81.0	98.25	101.20	100.88
	5.0	99.98	135.0	99.01	98.58	98.95
	7.0	99.05	189.0	98.58	100.51	100.38
Mean ± SD		99.75 ± 0.62		98.61 ± 0.38	100.10 ± 1.36	100.07 ± 1.00
-value		0.402 (2.776)^b		2.354 (2.776)^b
-value		4.829 (19.00)^b		6.91 (19.00)^b

Each result is the average of three separate determinations.
Values between parentheses are the tabulated - and -values at [29].