Research Article
Simultaneous HPLC Determination of Chlordiazepoxide and Mebeverine HCl in the Presence of Their Degradation Products and Impurities
Table 4
Application of the proposed method for the determination of CDO, MBV, and their degradation products in binary mixtures.
| Parameter | Conc. taken (µg/mL) | % founda | CDO | MBV | CDO | MBV |
| Binary mixture of CDO/MBV | 3.0 | 81.0 | 99.82 | 99.87 | 5.0 | 135.0 | 98.52 | 100.58 | 7.0 | 189.0 | 98.65 | 99.08 | Mean ± SD | | | 98.99 ± 0.72 | 99.84 ± 0.75 | % RSD | | | 0.72 | 0.75 | % error | | | 0.41 | 0.43 |
| | Conc. taken (µg/mL) | % found of CDOa | | | CDO | ACB | |
| Binary mixture of CDO/ACB | 100.0 | 2.0 | 99.08 | | 100.0 | 4.0 | 98.70 | | 100.0 | 8.0 | 99.12 | | 100.0 | 10.0 | 100.01 | | Mean ± SD | | | 99.22 ± 0.56 | | % RSD | | | 0.56 | | % error | | | 0.32 | |
| | Conc. taken (µg/mL) | % found of MBVa | | MBV | VER |
| Binary mixture of MBV/VER | 200.0 | 2.0 | 100.20 | | 200.0 | 4.0 | 99.68 | | 200.0 | 8.0 | 100.03 | | 200.0 | 10.0 | 99.98 | | Mean ± SD | | | 99.97 ± 0.22 | | % RSD | | | 0.22 | | % error | | | 0.08 | |
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Each result is the average of three separate determinations.
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